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製品番号: HY-N13095

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(+)-Plakevulin A

(+)-Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+)-Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+)-Plakevulin A induces apoptosis and shows anticancer activity.

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CAS 番号: 518035-27-3
分子式: C₂₃H₄₂O₄
分子量:382.58

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

(+)-Plakevulin A 構造式

CAS 番号: 518035-27-3

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価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

DNA Polymerase

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	11.5 μM Compound: (+)-1	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
HL-60	IC₅₀	2.02 μM Compound: (+)-1	Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
HL-60	IC₅₀	2.63 μM Compound: (+)-1	Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 48 hrs by WST-8 assay Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 48 hrs by WST-8 assay	[PMID: 38996938]
MC3T3-E1	IC₅₀	12.38 μM Compound: (+)-1	Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
MRC5	IC₅₀	>15 μM Compound: (+)-1	Cytotoxicity against human MRC5 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]

化学情報

CAS 番号 518035-27-3
分子量 382.58
分子式 C₂₃H₄₂O₄
SMILES

COC([C@H]1[C@@](O)(C=C[C@@H]1O)CCCCCCCCCCCCCCCC)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animals
Okinawan sponge Plakortis sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kabasawa M, et al . Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorg Med Chem Lett. 2024 Sep 15;110:129886. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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(+)-Plakevulin A

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

(+)-Plakevulin A 関連分類

HY-N13095 関連分類