PMEG
PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma[1][2].
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 114088-58-3
- 分子式: C8H12N5O5P
- 分子量:289.19
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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DNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Ca-Ski | EC50 |
5530 nM
Compound: PMEG
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Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
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[PMID: 19398642] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 114088-58-3
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分子量 289.19
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分子式 C8H12N5O5P
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SMILES
O=C1N=C(NC2=C1N=CN2CCOCP(O)(O)=O)N
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別名
9-(2-Phosphonylmethoxy)ethylguanine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kim HT, et al. Antiviral activity of 9-[[(ethoxyhydroxyphosphinyl)-methoxy]methoxy] guanine against cytomegalovirus and herpes simplex virus. Antiviral Res. 1995 Nov;28(3):243-51. [Content Brief]
[2]. Vail DM, et al. Assessment of GS-9219 in a pet dog model of non-Hodgkin's lymphoma. Clin Cancer Res. 2009;15(10):3503-3510. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PMEG 関連分類
HY-185150 関連分類
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- PMEG
- 114088-58-3
- 9-(2-Phosphonylmethoxy)ethylguanine
- DNA/RNA Synthesis
- CMV
- lymphoid cells
- DNA synthesis
- dividing cells
- leukemia
- rodent models
- client-owned pet dogs
- cytotoxicity
- anticancer agent
- ε
- high-proliferation lymphoid malignancies
- non-hodgkin's lymphoma
- spontaneous non-Hodgkin's lymphoma
- nuclear DNA polymerases α
- δ
- DNA chain termination
- melanoma
- Inhibitor
- inhibitor
- inhibit