Poncirin
Based on 4 publication(s) in Google Scholar
Poncirin is isolated from Poncirus trifoliata with anti-inflammory activites. Poncirin significantly reduces mechanical hyperalgesia and allodynia in Complete Freund’s Adjuvant (CFA)-induced inflammatory pain models.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.98%
- CAS 番号: 14941-08-3
- 分子式: C28H34O14
- 分子量:594.56
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Poncirin (Standard)Anti-Hyperalgesia Agent -
HY-N0528
LinarinAChE Inhibitor -
HY-N0528R
Linarin (Standard)AChE Inhibitor
MedChemExpress（MCE）の使用を引用している文献 Poncirin
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Flow Cytometry
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WB
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In Vivo Efficacy Study
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Histological Imaging/Staining
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 14941-08-3
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性状 Solid
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分子量 594.56
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分子式 C28H34O14
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Color White to off-white
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SMILES
O=C(C[C@@H](C1=CC=C(OC)C=C1)OC2=CC(O[C@H](O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]3O[C@@](O[C@@H](C)[C@H](O)[C@H]4O)([H])[C@@H]4O)=C5)C2=C5O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Eur J Pharmacol
Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling. [Abstract]2022 Feb 15:917:174759. PMID: 35032487
Poncirin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Feb 15:917:174759. [Abstract]
Effect of different concentrations of Poncirin (Pon) (12.5, 25, 50, 100, 150 μM) pretreatment on cell viabilities after A/R.
Poncirin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Feb 15:917:174759. [Abstract]
Poncirin (Pon) (50 μM) pretreatment reduced peak ROS accumulation induced by A/R as measured by DCF staining and flow cytometry.
Poncirin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Feb 15:917:174759. [Abstract]
Representative Western blot image and graph showing quantification of cleaved caspase 3 treated with Poncirin (Pon) (50 μM).
Poncirin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Feb 15:917:174759. [Abstract]
Myocardial infarction size was determined by TTC staining treated with Poncirin (Pon) (30 mg/kg).
Poncirin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Feb 15:917:174759. [Abstract]
Poncirin (30 mg/kg) preserved myocardial structure and prevents inflammation induced by I/R in rats.
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Plants
Determination of Flavonoid Glycoside Isomers Using Vision Transformer and Tandem Mass Spectrometry. [Abstract]2024 Dec 4;13(23):3401. PMID: 39683194
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (168.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.20 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.20 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (274 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6819 mL | 8.4096 mL | 16.8192 mL | 42.0479 mL |
| 5 mM | 0.3364 mL | 1.6819 mL | 3.3638 mL | 8.4096 mL | |
| 10 mM | 0.1682 mL | 0.8410 mL | 1.6819 mL | 4.2048 mL | |
| 15 mM | 0.1121 mL | 0.5606 mL | 1.1213 mL | 2.8032 mL | |
| 20 mM | 0.0841 mL | 0.4205 mL | 0.8410 mL | 2.1024 mL | |
| 25 mM | 0.0673 mL | 0.3364 mL | 0.6728 mL | 1.6819 mL | |
| 30 mM | 0.0561 mL | 0.2803 mL | 0.5606 mL | 1.4016 mL | |
| 40 mM | 0.0420 mL | 0.2102 mL | 0.4205 mL | 1.0512 mL | |
| 50 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8410 mL | |
| 60 mM | 0.0280 mL | 0.1402 mL | 0.2803 mL | 0.7008 mL | |
| 80 mM | 0.0210 mL | 0.1051 mL | 0.2102 mL | 0.5256 mL | |
| 100 mM | 0.0168 mL | 0.0841 mL | 0.1682 mL | 0.4205 mL |
Poncirin 関連分類
HY-N2258 関連分類
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