Tec
null The Tec family of non-receptor tyrosine kinases contains five mammalian members: BTK, ITK, TEC, TXK (RLK) and BMX (ETK). A hallmark is the N-terminal pleckstrin-homology domain (replaced by cysteine-rich regions in TXK) that binds phosphoinositides and recruits the kinases to the plasma membrane upon PIP3 generation. Tec kinases act downstream of antigen receptors, toll-like receptors and integrins in B cells, T cells, macrophages and platelets, phosphorylating PLCγ to generate calcium and diacylglycerol signals. BTK mutations cause X-linked agammaglobulinemia, proving BTK's essential role in B-cell development. Bruton tyrosine kinase inhibitors such as ibrutinib, acalabrutinib and zanubrutinib revolutionized therapy of B-cell malignancies.
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Tec 組換えタンパク質 (24)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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