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プニカラギン

(別名: Punicalagin)
17 Cited Publications
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Based on 17 publication(s) in Google Scholar

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.89%
  • CAS 番号: 65995-63-3
  • 分子式: C48H28O30
  • 分子量:1084.72
  • 保管条件:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Punicalagin Chemical Structure
    Punicalagin 構造式
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
CAS 番号: 65995-63-3
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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  • Punicalagin Chemical Structure
    Punicalagin Chemical Structure
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  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. The mRNA expression of the inflammatory factors Ccl6, Lgals3, C1qa, TYROBP, and CD74 in the brain tissues 48 h postoperatively, normalized to GAPDH for each sample. PUN can effectively reduce the inflammatory response in brain tissue after HIE, while the AKT signaling pathway inhibitor 3-MA reversed this therapeutic effect.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative images of HE staining in the cortex post-operatively.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative Western blot images and quantification of Bcl-2 and Bax expression three days post-operation in the cortex.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative TUNEL-stained (green) and DAPI-stained (blue) brain sections of the cortex three days post-operatively. Quantitative analysis of the percentage of TUNEL-positive cells in the cortex.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative images of immunohistochemical staining of p-AKT and immunofluorescence staining for p62 (red) and LC3 (green) in the cortex of each group at 72 h post-HI.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3. [Abstract]

    Customer Validation
     Body weight changes in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3. [Abstract]

    Customer Validation
     T-705 and SAA significantly reduced viral copies in the liver in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

  • Punicalagin