27 Results for "

GRP-R

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "GRP-R" in MCE Product Catalog:

1
1 Cited Publications
製品番号: HY-P0107A
CAS 番号: 1217463-61-0
Target:  

Bombesin Receptor

研究分野:  

Inflammation/Immunology

RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .
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1
1 Cited Publications
製品番号: HY-P0107
CAS 番号: 138147-78-1
Target:  

Bombesin Receptor

研究分野:  

Inflammation/Immunology

RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .
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1
1 Cited Publications
製品番号: HY-P10896
CAS 番号: 1446005-10-2
Target:  

Bombesin Receptor

研究分野:  

Cancer

NOTA-P2-RM26 is an antagonist of Bombesin (HY-P0195) analogs, and the gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for prostate cancer visualization. NOTA-P2-RM26 is labeled with 111In and 68Ga for prostate cancer imaging studies using PET and SPECT/CT .
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製品番号: HY-N2909
CAS 番号: 58115-31-4
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models .
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製品番号: HY-W782083
CAS 番号: 1583289-85-3
p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer .
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製品番号: HY-N2600
CAS 番号: 76472-87-2
Kuwanon H is a selective non-peptide bombesin receptor antagonist and platelet activation inhibitor. Kuwanon H also acts as a specific antagonist of GRP-preferring receptors, with a Ki value of 290 nM for mouse GRP-R and 6500 nM for rat NMB-R. Kuwanon H inhibits the phosphorylation of AKT, mTOR, ERK, cPLA2 and p38, and upregulates TRIB3. It induces endoplasmic reticulum stress, apoptosis and autophagosome formation. Kuwanon H blocks calcium mobilization, mitogenic signaling, DNA synthesis, dense granule secretion, thromboxane A2 generation and integrin αIIb/β3 activity. It inhibits collagen-induced platelet aggregation and fibronectin adhesion, and delays clot retraction. Kuwanon H inhibits melanoma cell growth in vitro and in vivo, and enhances the sensitivity of melanoma cells to CDDP. It can be used in research related to melanoma, small cell lung cancer and thrombosis .
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製品番号: HY-116216
CAS 番号: 204066-82-0
純度:  98.78%
Target:  

Bombesin Receptor

研究分野:  

Cancer

PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the Ki of 15–45 nM . PD 168368 is neuromedin B receptor (NMBR; IC50=96 nM) / gastrin-releasing peptide receptor (GRPR IC50=3500 nM) antagonist . PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50s of 0.57, 0.24, and 2.7 nM, respectively .
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製品番号: HY-P1423A
Target:  

Bombesin Receptor

研究分野:  

Metabolic Disease Cancer

BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC50s of 6, 0.4, 2.5 nM .
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製品番号: HY-P0039
CAS 番号: 136207-23-3
Target:  

Bombesin Receptor

研究分野:  

Cancer

BIM-26226 is a selective gastrin-releasing peptide receptor (GRPR) (IC50 = 6 nM) and bombesin receptor (BN receptor) antagonist. BIM-26226 antagonizes BN- or GRP-stimulated amylase release with IC50 values of 0.3 nM and 0.2 nM, respectively. BIM-26226 is specific for the GRP-preferring BN receptor subtype with no interference with GRP receptor system. BIM-26226 can induce the synthesis of somatostatin receptor but has no significant effect on tumor growth .
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製品番号: HY-115974
CAS 番号: 3052544-28-9
Target:  

Bombesin Receptor

研究分野:  

Cancer

GRPR antagonist-1 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis, with anticancer activity .
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製品番号: HY-W343750
CAS 番号: 67338-70-9
Target:  

Bombesin Receptor

研究分野:  

Metabolic Disease

[Tyr4]-Bombesin is a Bombesin analogue, is a ligand of gastrin-releasing peptide receptor (GRPR) .
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製品番号: HY-P5413
CAS 番号: 66839-66-5
研究分野:  

Others

[Lys3]-Bombesin is a biological active peptide. (PET (Positron Emission Tomography) imaging of [Lys3]-bombesin is able to detect gastrin-releasing peptide receptor (GRPR) positive prostate cancer. An immunoconjugate of [Lys3]-bombesin and corresponding monoclonal antibody can specifically induce (CD64)-dependent monocyte and neutrophil-mediated lysis of small cell carcinoma.)
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製品番号: HY-P11352
CAS 番号: 202344-21-6
別名: RM26
Target:  

Bombesin Receptor

研究分野:  

Cancer

JMV594 (Compound RM 26) is a bombesin analogue with high affinity and antagonistic effect for gastrin releasing peptide receptor (GRPR).JMV594 can be used for the research of cancer, such as Prostate cancer .
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製品番号: HY-176150
Target:  

Bombesin Receptor

研究分野:  

Cancer

AMTG-DA1 is a Gastrin-releasing peptide receptor (GRPR) ligand. AMTG-DA1 can be used in the study of cancer .
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製品番号: HY-P5520
CAS 番号: 2413262-74-3
GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects .
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製品番号: HY-P1423
CAS 番号: 183241-31-8
Target:  

Bombesin Receptor

研究分野:  

Metabolic Disease Cancer

BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC50s of 6, 0.4, 2.5 nM .
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製品番号: HY-168633
Target:  

Bombesin Receptor PSMA

研究分野:  

Cancer

PSMA/GRPR ligand 1 (compound 3 ) is a bispecific PSMA/GRPR ligand that shows dual targeting for PSMA(+) and GRPR(+) tumors .
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製品番号: HY-115975
CAS 番号: 3052544-42-7
Target:  

Bombesin Receptor

研究分野:  

Cancer

GRPR antagonist-2 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 0.77 and 2.5 μM in HGC-27 and Pan02 cells, respectively). Anticancer activity .
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製品番号: HY-RS05847
研究分野:  

Others

GRPR Human Pre-designed siRNA Set A contains three designed siRNAs for GRPR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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製品番号: HY-P790077
純度:  ≥ 90%, as determined by reducing SDS-PAGE.
別名: GRPR; BRS2; Gastrin Releasing Peptide Receptor; BB2; Gastrin-Releasing Peptide Receptor; Bombesin Receptor 2; GRP-Preferring Bombesin Receptor; GRP-R; BB2R
Species:  
Human
Source:  
E. coli Cell-free
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