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Sirukumab

(別名: CNTO-136)
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Based on 1 Customer Validation

Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • 純度: 96.83%
  • CAS 番号: 1194585-53-9
  • 分子量:144.58 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sirukumab
  • Experimental Validation Results for Sirukumab
  • Experimental Validation Results for Sirukumab
  • Sirukumab Chemical Structure
    Sirukumab 構造式
CAS 番号: 1194585-53-9
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IL-6 Protein can bind Sirukumab. The EC50 for this effect is 1.86 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Siha cells labeling Sirukumab (HY-P99316, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sirukumab Chemical Structure
    1/16
  • Sirukumab
  • Immobilized Human IL-6 Protein can bind Sirukumab. The EC50 for this effect is 1.86 ng/mL.
  • Flow cytometric analysis of 1.5×106 Siha cells labeling Sirukumab (HY-P99316, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).