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製品番号: HY-N1240

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Sissotrin

Name: Sissotrin
Brand: MedChemExpress
SKU: HY-N1240
Price: 145.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: Biochanin A 7-glucoside; Sissonin)

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Based on 1 Customer Validation

Sissotrin (Biochanin A 7-glucoside; Sissonin) is an orally active isoflavone glycoside natural product found in Leguminosae plants, with weak antibacterial activity. Sissotrin exacerbates the increase in blood glucose after glucose loading. Sissotrin is used in studies related to glucose metabolism.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 98.46%
CAS 番号: 5928-26-7
分子式: C₂₂H₂₂O₁₀
分子量:446.40

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sissotrin 構造式

CAS 番号: 5928-26-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体外実験

Oxidative StressBacterial InfectionOthers

Oxidative Stress

Sissotrin (compound 1) (1-1000 μM; 10 min) fails to protect HUVEC against H₂O₂-induced oxidative damage ^[1].

Bacterial Infection

Sissotrin (compound 1) (500-3.906 μg/mL; 24 h) exhibits weak antibacterial activity against Shigella flexneri CPC (MIC = 250 μg/mL) and Shigella flexneri NR 518 (MIC = 500 μg/mL), but shows no activity against Staphylococcus aureus ATCC 43300, Methicillin-resistant (HY-121544) Staphylococcus aureus 33591, Escherichia coli ATCC 25922, and Staphylococcus aureus CPC^[3].

Others

Sissotrin is an isoflavone glucoside obtained via microbial glycosylation of Biochanin A (HY-14595)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HUVEC
Concentration:

1, 3, 10, 30, 100, 300, 1000 μM
Incubation Time:

10 min (pre-incubation)
4 h (H₂O₂ challenge)
Result:

Did not prevent cellular damage induced by H2O2.
Did not show toxicity to the cells at concentrations up to 1 mM.

体内実験

Carbohydrate Metabolism

Sissotrin (50-100 mg/kg, p.o., administered 10 min before glucose load) impairs glucose tolerance and exacerbates post-load hyperglycemia in normal Wistar rats in the OGTT^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (Male, 140-170 g)^[2]
Dosage:

50, 100 mg/kg
Administration:

p.o.; single administration 10 min prior to glucose load
Result:

Caused a significant rise in blood glucose levels at 15, 30 and 60 min after the glucose load.
At 30 min after the glucose load, blood glucose was 172 mg/dL for 100 mg/kg versus 144 mg/dL for control.
Produced 133 mg/dL at 50 mg/kg.
The hyperglycaemic effect observed at 100 mg/kg was abolished at the lower dose of 50 mg/kg.

Related Protocols :

化学情報

CAS 番号 5928-26-7
性状 Solid
分子量 446.40
分子式 C₂₂H₂₂O₁₀
Color White to off-white
SMILES

O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
別名

Biochanin A 7-glucoside; Sissonin
Structure Classification
- Flavonoids
- Isoflavones
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Vitor RF, et al. Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury. Journal of ethnopharmacology. 2004 Aug;93(2-3):363-70.

[2]. Paulo A, et al. The opposing effects of the flavonoids isoquercitrin and sissotrin, isolated from Pterospartum tridentatum, on oral glucose tolerance in rats. Phytotherapy research : PTR. 2008 Apr;22(4):539-43.

[3]. Tsamo D L F, et al. Semisynthetic Derivatives of Sissotrin Isolated from Trifolium baccarinii (Fabaceae) and Evaluation of Their Antibacterial Activities. Advances in Biological Chemistry, 2024, 14: 27-39.

[4]. Sordon S, et al. Microbial Glycosylation of Daidzein, Genistein and Biochanin A: Two New Glucosides of Biochanin A. Molecules (Basel, Switzerland). 2017 Jan 03;22(1):81.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Sissotrin

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Sissotrin

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Sissotrin 関連分類

HY-N1240 関連分類

Bioz

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最近チェックした製品