Solanidine
Based on 1 publication(s) in Google Scholar
Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 80-78-4
- 分子式: C27H43NO
- 分子量:397.64
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Solanidine
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生物活性
Solanidine (10 μM) increases the proliferation of MCF-7 human breast cancer cells in the estrogen-depleted condition[1].
Solanidine (4-8 μM; 48 h) induces DNA damage in A549 cells and reduces the migration and invasion of A549 cells under hypoxic conditions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:4 μM, 8 μM
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Incubation Time:48 h
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Result:Decreased the expression of RAD51, elevated the expression of γH2AX, and increased the expression of tumor suppressor protein p53.
Inhibited the phosphorylation of ATMser1981, HIF-1αser696, and Chk2Tyr68.
Solanidine (4-8 μM; topical application; 7 days) reduces neovascularization in the alkali burn corneal model of rats[2].
Solanidine (10-20 mg/kg; i.p.; every other day; 6 doses) regresses LLC tumor in Balb/C female mice, reduces the number of tumor nodules, and extends the survival of animals[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Webster mice (female, 25-36 g, timed-pregnant at 1-2 days’ gestation) pregnant mice model[1]
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Dosage:2.4 mmol/kg (in diet)
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Administration:Dietary administration, 14 days
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Result:Led to lower body weight gains, litter weights, and average fetus weights in pregnant mice.
Resulted in miscarriage in 5 of 24 pregnant mice.
Increased liver weight as a percentage of body weight (%LW/BW) in non-pregnant and pregnant mice.
Showed lower litter weight as a percentage of body weight (%LTW/BW).
化学情報
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CAS 番号 80-78-4
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性状 Solid
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分子量 397.64
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分子式 C27H43NO
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Color White to off-white
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SMILES
[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
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別名
ソラニジン
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
Ethanol : 3.33 mg/mL (8.37 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. Friedman M, et al. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 2003 Jan;41(1):61-71. [Content Brief]
[2]. Sherapura A, et al. Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma. Phytomedicine. 2023 Oct;119:154981. [Content Brief]
[3]. Zhang ZD, et al. Synthesis of Demissidine and Solanidine.Org Lett. 2016 Jun 17;18(12):3038-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.5148 mL | 12.5742 mL | 25.1484 mL | 62.8709 mL |
| 5 mM | 0.5030 mL | 2.5148 mL | 5.0297 mL | 12.5742 mL |
Solanidine 関連分類
HY-N7271 関連分類
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