製品番号: HY-N0070

Solasonine

(別名: ソラソジン)

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.0%
CAS 番号: 19121-58-5
分子式: C₄₅H₇₃NO₁₆
分子量:884.06

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solasonine 構造式

CAS 番号: 19121-58-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
Publications (3)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

GPX4

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示 :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	11.4 μg/mL Compound: solasonine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8450317]
PLC-PRF-5	ED₅₀	7.88 μg/mL Compound: solasonine	Cytotoxicity against human PLC/PRF/5 cells Cytotoxicity against human PLC/PRF/5 cells	[PMID: 8450317]

体外実験

Solasonine (2.5-50 ng/mL, 24 h) inhibits cell viability of HepG2 and HepRG in a dose-dependent manner with IC₅₀s of about 15 ng/mL for both HepG2 and HepRG^[2].
Solasonine (15 ng/mL, 24 h) significantly increases the proportions of apoptotic HepG2 and HepRG cells from about 4% to more than 20 %^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 19121-58-5
性状 Solid
分子量 884.06
分子式 C₄₅H₇₃NO₁₆
Color White to light yellow
SMILES

C[C@H](CC1)CN[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O[C@@]7([H])[C@H](O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O[C@@]9([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O9)[C@@H](O)[C@@H](CO)O7)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
別名

ソラソジン
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

All Cell Proliferation/Viability AssayCell Imaging/StainingFlow CytometryWBIF

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Journal Impact Factor

Front Oncol

Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma. [Abstract]

2022 May 18:12:874900. PMID: 35664792

Solasonine purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 May 18:12:874900. [Abstract]

The cell viability of Calu-1 and A549 cells was measured using the CCK-8 assay after SS treatment for 24 h.

Solasonine purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 May 18:12:874900. [Abstract]

Microscope observation of Calu-1 or A549 cells treated with 10, 15, 20 μM or 20, 25, 30 μM of Solasonine (SS) for 24 h, respectively.

Solasonine purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 May 18:12:874900. [Abstract]

Flow cytometry were used to detect ROS production in Calu-1 or A549 cells treated for 6 h with 10, 15, 20 μM or 20, 25, 30 μM Solasonine (SS) and pretreated with or without Fer-1 (1 μM).

Solasonine purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 May 18:12:874900. [Abstract]

Western blot analysis was used to detect the expressions of SLC7A11 and GPX4 in Calu-1 cells, which were treated with 10, 15, 20 μM Solasonine (SS) for 6 h.

Solasonine purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 May 18:12:874900. [Abstract]

Fluorescence microscopy was used to detect the lipid ROS production in Calu-1cells, which were treated with 20 μM Solasonine (SS) for 6 h and pretreated with or without Trolox (100 mM) or Mito TEMPO (10 mM).
Adv Biol (Weinh)

Solasonine Restores Sensitivity of Gastric Cancer to NK Cells through DNA Demethylation of MICA. [Abstract]

2025 Aug 7:e00793. PMID: 40772533
bioRxiv

2024 Mar 20.

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (113.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1311 mL

5.6557 mL

11.3114 mL

5 mM

0.2262 mL

1.1311 mL

2.2623 mL

10 mM

0.1131 mL

0.5656 mL

1.1311 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ding X, et al. Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.). Food Chem. 2013 Nov 15;141(2):1181-6. [Content Brief]

[2]. Jin M, et al. Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system. Biomed Pharmacother. 2020 Sep;129:110282. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1311 mL	5.6557 mL	11.3114 mL	28.2786 mL
	5 mM	0.2262 mL	1.1311 mL	2.2623 mL	5.6557 mL
	10 mM	0.1131 mL	0.5656 mL	1.1311 mL	2.8279 mL
	15 mM	0.0754 mL	0.3770 mL	0.7541 mL	1.8852 mL
	20 mM	0.0566 mL	0.2828 mL	0.5656 mL	1.4139 mL
	25 mM	0.0452 mL	0.2262 mL	0.4525 mL	1.1311 mL
	30 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9426 mL
	40 mM	0.0283 mL	0.1414 mL	0.2828 mL	0.7070 mL
	50 mM	0.0226 mL	0.1131 mL	0.2262 mL	0.5656 mL
	60 mM	0.0189 mL	0.0943 mL	0.1885 mL	0.4713 mL
	80 mM	0.0141 mL	0.0707 mL	0.1414 mL	0.3535 mL
	100 mM	0.0113 mL	0.0566 mL	0.1131 mL	0.2828 mL

Keywords

Solasonine

3 Cited Publications

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Solasonine

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MedChemExpress（MCE）の使用を引用している文献 Solasonine

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (3)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Solasonine 関連分類

HY-N0070 関連分類