Spesolimab (WT IgG1)
Based on 1 Customer Validation
Spesolimab (BI 655130) (WT IgG1) is a mouse-derived humanized IgG1k antibody against IL-36R. Spesolimab (WT IgG1) retains the native wild-type Fc. Spesolimab (WT IgG1) is associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways. Spesolimab (WT IgG1) is being investigated in palmoplantar pustulosis (PPP).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.10%
- CAS 番号: 2097104-58-8
- 分子量:145.5 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Isotype
Human IgG1 (L234A/L235A) kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IL-1RL2/IL-36R
体外実験
The Ka (M-1s-1) of spesolimab is 1.36×106, Kd (s-1) is 3.28×10-5, KD (pM) is 24, the IC90 is 0.9 nM in the NCI/ADR-RES ovarian epithelial cell line and the IC90 is 1.9 nM in primary human dermal fibroblasts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized IL-1RL2 Protein, Human (HEK293, His, HY-P70603) can bind Spesolimab. The EC50 for this effect is 6.924 ng/mL.
化学情報
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CAS 番号 2097104-58-8
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性状 Liquid
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分子量 145.5 kDa
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Color Colorless to light yellow
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SMILES
[Spesolimab (WT IgG1)]
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別名
BI 655130 (WT IgG1)
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Mrowietz U, et al. Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study. Dermatol Ther (Heidelb). 2021 Apr;11(2):571-585. [Content Brief]
[3]. Jennifer Ahlberg, et al. Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5). MAbs. 2019 Jul;11(5):956-964. [Content Brief]
[4]. Rajkumar Ganesan, et al. Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.MAbs. 2017 Oct;9(7):1143-1154. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)