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製品番号: HY-187907

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Surbinsertib

Name: Surbinsertib
Brand: MedChemExpress
SKU: HY-187907
Availability: PreOrder

(別名: SGR-3515)

Surbinsertib (SGR-3515) is an orally active dual inhibitor of the Wee1 and Myt1 kinases. Surbinsertib is used in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3038330-83-2
分子式: C₃₀H₄₀N₈O₂S
分子量:576.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Surbinsertib 構造式

CAS 番号: 3038330-83-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Surbinsertib (SGR-3515) is an orally active dual inhibitor of the Wee1 and Myt1 kinases. Surbinsertib is used in cancer research^[1]^[2].

Wee1 アイソフォーム固有の製品をすべて表示 :

PKMYT1

体外実験

Both Wee1 and Myt1 are CDK-inhibitory kinases. Wee1 primarily phosphorylates CDK1‑Tyr15, while Myt1 phosphorylates both CDK1‑Tyr15 and Thr14. The two kinases act synergistically to inhibit CDK1 activity and regulate the G2/M cell cycle transition.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3038330-83-2
分子量 576.76
分子式 C₃₀H₄₀N₈O₂S
SMILES

C[C@]12[C@](CC(C)(OC2)C)([H])N(C3=CC=CC(N=S(C)(C)=O)=N3)C4=NC(NC5=CC=C(N6CCN(CC6)C)C=C5)=NC=C41
別名

SGR-3515
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. WHO Drug Information, Vol. 40, No. 2, 2026

[2]. Shaoxian Sun, et al, Abstract 3025: Optimization of therapeutic index of SGR-3515, a first-in-class Wee1/Myt1 inhibitor through intermittent dosing for monotherapy and combination with chemotherapy in xenograft tumor models. Cancer Res 15 April 2025; 85.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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