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Tanezumab

(別名: RN-624; PF 4383119)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.52%
  • CAS 番号: 880266-57-9
  • 分子量:145.44 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tanezumab
  • Experimental Validation Results for Tanezumab
  • Experimental Validation Results for Tanezumab
  • Tanezumab Chemical Structure
    Tanezumab 構造式
CAS 番号: 880266-57-9
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Immobilized Beta-NGF Protein, Human, HEK293, HY-P7660 can bind Tanezumab. The EC50 for this effect is 5.218 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 SHSY5Y cells labeling Tanezumab (HY-P99221, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Tanezumab Chemical Structure
    1/16
  • Tanezumab
  • Immobilized Beta-NGF Protein, Human, HEK293, HY-P7660 can bind Tanezumab. The EC50 for this effect is 5.218 ng/mL.
  • Flow cytometric analysis of 1.5×106 SHSY5Y cells labeling Tanezumab (HY-P99221, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).