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TGN-020

25 Cited Publications
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Based on 25 publication(s) in Google Scholar

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • 純度: 99.97%
  • CAS 番号: 51987-99-6
  • 分子式: C8H6N4OS
  • 分子量:206.23
  • 保管条件:

    Store at room temperature 3 years.

    In solvent   -80°C, 2 years , -20°C, 1 year
  • TGN-020 Chemical Structure
    TGN-020 構造式
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
CAS 番号: 51987-99-6
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MedChemExpress（MCE）の使用を引用している文献 TGN-020

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In Vivo Efficacy StudyHistological Imaging/StainingIFWB
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • WB
  • WB
  • IF
  • Histological Imaging/Staining

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  • TGN-020 Chemical Structure
    TGN-020 Chemical Structure
    1/16
  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     TGN-020 (0.1 mg/20 g, administered via intraperitoneal injection every 12 h). Representative T2WI and DWI images of three distinct mouse groups.

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     Schematic of intracerebral injection procedure in mice. Representative fluorescence microscopy images show Ovalbumin (45-kDa, red) inflow into CSF at 30- and 60-minute. The white arrow indicates the residual tracer deposition. Scale bar: 1000 μm. Quantification of Ovalbumin inflow at 30- and 60-minute in brain sections (n = 4 mice per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     TGN-020 (0.1 mg/20 g, administered via intraperitoneal injection every 12 h). Representative Western blot bands and densitometric quantification of AQP4-M1 and AQP4-M23 in the peri-infarction area (n = 6 per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     TGN-020 (100 mg/kg, i.p.,on the third day) Representative immunoblot bands and densitometric quantification of TH, GFAP, AQP4-M1, AQP4-M23, and AQP4-M23/M1 (n = 6 per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     TGN-020 (100 mg/kg, i.p., on the third day).Representative 20 × magnification immunofluorescence images of AQP4 (red) and GFAP (green) in the striatum and SN. White dotted squares show the colocalization of AQP4 with astrocyte endfeet.

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     Quantification of the mean intensity of A594 penetration into the whole brain parenchyma in both Saline and MPTP groups after inhibition of TGN-020 (100 mg/kg, i.p., on the third day) (n = 4–5 per group).

  • TGN-020