TMP920
Based on 1 Customer Validation
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.92%
- CAS 番号: 1421837-45-7
- 分子式: C29H30N2O3
- 分子量:454.56
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-14422
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CintirorgonRORγ Agonist -
HY-16998
SR2211RORγ Inverse Agonist -
HY-19774
GNE-0946RORγ/RORc Agonist -
HY-120210
XY018ROR-γ Antagonist -
HY-132810
BevurogantRORγt Antagonist -
HY-19770
GSK2981278RORγ Inverse Agonist
生物活性
製品説明
IC50 & Target
IC50: 0.03 μM (RORγt)[1]
体外実験
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Na?ve CD4+ T cells[1].
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TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro[1].
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TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro[1].
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TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets[1].
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TMP920 significantly reduces RORγt-DNA interactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Naïve CD4 + T cells
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Concentration:0.09-30 μM
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Incubation Time:48 hours
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Result:Has toxic effects on cell growth at >10 μM.
化学情報
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CAS 番号 1421837-45-7
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性状 Solid
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分子量 454.56
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分子式 C29H30N2O3
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Color White to off-white
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SMILES
O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : 62.5 mg/mL (137.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1999 mL | 10.9996 mL | 21.9993 mL | 54.9982 mL |
| 5 mM | 0.4400 mL | 2.1999 mL | 4.3999 mL | 10.9996 mL | |
| 10 mM | 0.2200 mL | 1.1000 mL | 2.1999 mL | 5.4998 mL | |
| 15 mM | 0.1467 mL | 0.7333 mL | 1.4666 mL | 3.6665 mL | |
| 20 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7499 mL | |
| 25 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.1999 mL | |
| 30 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
| 40 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3750 mL | |
| 50 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL | |
| 60 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9166 mL | |
| 80 mM | 0.0275 mL | 0.1375 mL | 0.2750 mL | 0.6875 mL | |
| 100 mM | 0.0220 mL | 0.1100 mL | 0.2200 mL | 0.5500 mL |
TMP920 関連分類
HY-117819 関連分類
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