TP-051
TP-051, a chemical probe, is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 858097-86-6
- 分子式: C29H31FO6S
- 分子量:526.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Ki: 16 nM (human FFAR1)[1]
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
25 nM
Compound: 31
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Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA
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[PMID: 22428944] |
TP-051 (compound 31) (0.01-10 μM; 2 h; INS-1 cells) augments insulin secretion in a dose-dependent manner in the presence of 11 mM glucose and statistically significant increases in insulin secretion were observed at doses of above 0.1 μM of the compound[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 858097-86-6
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分子量 526.62
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分子式 C29H31FO6S
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SMILES
O=C(CCC1=CC=C(C=C1F)OCC2=CC=CC(C3=C(C)C=C(C=C3C)OC4CCS(=O)(CC4)=O)=C2)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TP-051 関連分類
HY-148235 関連分類
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