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製品番号: HY-181890

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TRG-192

TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC₅₀ of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer.

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CAS 番号: 3080792-24-8
分子式: C₂₄H₂₀F₆N₈O₂S₂
分子量:630.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

TRG-192 構造式

CAS 番号: 3080792-24-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

IC₅₀: 68 nM (GLS)^[1]

体外実験

TRG-192 potently inhibits glutaminase in cell-free in vitro biochemical assays, with an IC₅₀ of 68 nM^[1].
TRG-192 (0.01-1 μM; 72 h) potently inhibits the proliferation of glutamine-addicted NSCLC cell lines (A549, H460, H358), with IC₅₀ values of 0.068 μM, 0.038 μM and 0.035 μM respectively after 72 h of treatment^[1].
TRG-192 (0.3 μM; 24 h) significantly reduces intracellular glutamate levels in LDK378-resistant (LR) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3080792-24-8
分子量 630.59
分子式 C₂₄H₂₀F₆N₈O₂S₂
SMILES

O=C(NCC1=NC=CC(C(F)(F)F)=C1)C2=NN=C(CCCCC3=NN=C(C(NCC4=NC=CC(C(F)(F)F)=C4)=O)S3)S2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Cyriac R, et al. Design, synthesis and biological evaluation of symmetric thiadiazole carboxamide derivative as glutaminase inhibitor. Bioorg Med Chem Lett. Published online February 21, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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