Triacsin C
Based on 9 publication(s) in Google Scholar
Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Triacsin C exhibits highly inhibitory effect against rotavirus replication.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.71%
- CAS 番号: 76896-80-5
- 分子式: C11H17N3O
- 分子量:207.27
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Triacsin C
More- Sci Adv. 2023 Apr 14;9(15):eadf8522. [Abstract]
- Cancer Lett. 2024 Apr 10:587:216696. [Abstract]
- Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2319582121. [Abstract]
- Oncogene. 2025 Sep;44(34):3096-3112. [Abstract]
- Cell Rep. 2025 Aug 7;44(8):116100. [Abstract]
- Clin Transl Med. 2026 Jan;16(1):e70563. [Abstract]
- Brain Pathol. 2026 Mar 1:e70074. [Abstract]
- Int J Mol Sci. 2026 Mar 19;27(6):2778. [Abstract]
- Res Sq. 2026 Jun 15.
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Parasite アイソフォーム固有の製品をすべて表示
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生物活性
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ACSL4 |
Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively[3].
Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC50 value of 136 nM[3].
Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cryptosporidium-infected interleukin knockout mice[3]
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Dosage:8-15 mg/kg/d
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Administration:Oral gavage; 1 week
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Result:Reduced parasite oocyst production up to 88.1% with no apparent toxicity.
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Animal Model:Low-density lipoprotein receptor-knockout (LDLR-/-) mice (C57BL/6 background)[4]
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Dosage:10 mg/kg/d
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Administration:Oral gavage; 2 months
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Result:Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration.
Improved the growth of aortic atherosclerosis mice, increased the body weight of mince.
化学情報
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CAS 番号 76896-80-5
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性状 Solid
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分子量 207.27
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分子式 C11H17N3O
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Color Light yellow to brown
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SMILES
CCC/C=C/C/C=C/C=C/C=N/NN=O
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別名
WS 1228A; FR 900190; トリアクシンC
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Structure Classification
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Initial Source
Streptomyces aureofaciens
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (9)
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Journal Impact Factor
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Most Recent
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Sci Adv
M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism. [Abstract]2023 Apr 14;9(15):eadf8522. PMID: 37058562 -
Cancer Lett
2024 Apr 10:587:216696. PMID: 38331089
Triacsin C purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Apr 10:587:216696. [Abstract]
Triacsin C (1 and 5 μM, 12 h) decreased LDHA palmitoylation in PANC1 cells labeled with 50 μM alk-C16 for 8 h using the CCR method.
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Proc Natl Acad Sci U S A
2024 Mar 19;121(12):e2319582121. PMID: 38483998
Triacsin C purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2319582121. [Abstract]
Triacsin C (5 μM, 4 days) blocked the accumulation of triacylglycerol in lipid droplets, resulting in enlarged but reduced numbers of lipid droplets in the V. mali (QX-4-5) strain.
Triacsin C purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2319582121. [Abstract]
Triacsin C (5 μM, 4 days) increased the accumulation of VmNSRV1 genomic RNA in the V. mali(QX-4-5) strain.
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Oncogene
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation. [Abstract]2025 Sep;44(34):3096-3112. PMID: 40595416 -
Cell Rep
2025 Aug 7;44(8):116100. PMID: 40782351 -
Clin Transl Med
FABP4-mediated lipid droplet accumulation drives epithelial-mesenchymal transition and aggravates alveolar epithelial barrier disruption. [Abstract]2026 Jan;16(1):e70563. PMID: 41454478
Triacsin C purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2026 Jan;16(1):e70563. [Abstract]
Triacsin C (2 mg/kg, i.p., 24 h) reduced LIRI-induced lung injury in male C57BL/6J mice.
Triacsin C purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2026 Jan;16(1):e70563. [Abstract]
Triacsin C (5 μM, 8 h) preserved zonula occludens-1 (ZO-1) expression in MLE-12 cells.
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Brain Pathol
2026 Mar 1:e70074. PMID: 41765417 -
Int J Mol Sci
Deficiency of PTEN Confers Hypersensitivity to Fatty Acid-Mediated ER Stress in Transformed Hepatocytes. [Abstract]2026 Mar 19;27(6):2778. PMID: 41898638 -
溶剤 & 溶解度
DMSO : 5 mg/mL (24.12 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (394 KB)
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- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Dechandt CRP, et al. Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr. 2017 Oct;49(5):399-411. [Content Brief]
[2]. Kim Y, et al. Novel triacsin C analogs as potential antivirals against rotavirus infections. Eur J Med Chem. 2012 Apr;50:311-8. [Content Brief]
[3]. Guo F, et al. Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases. J Infect Dis. 2014 Apr 15;209(8):1279-87. [Content Brief]
[4]. Matsuda D, et al. Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. J Antibiot (Tokyo). 2008 May;61(5):318-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8246 mL | 24.1231 mL | 48.2462 mL | 120.6156 mL |
| 5 mM | 0.9649 mL | 4.8246 mL | 9.6492 mL | 24.1231 mL | |
| 10 mM | 0.4825 mL | 2.4123 mL | 4.8246 mL | 12.0616 mL | |
| 15 mM | 0.3216 mL | 1.6082 mL | 3.2164 mL | 8.0410 mL | |
| 20 mM | 0.2412 mL | 1.2062 mL | 2.4123 mL | 6.0308 mL |
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