UM206_L
UM206_L is a linear Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1242439-00-4
- 分子式: C54H90N16O23S3
- 分子量:1427.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
UM206_L (free form) (10 nM-1 mM; 3 h, 24 h) fails to stably regulate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells[1].
UM206_L-conjugated MNPs (1-10 µg per mg MNP; 1-24 h), when combined with 1 Hz nanomagnetic actuation, potently activate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells in a peptide density-dependent manner in vitro[1].
UM206_L (immobilized; 1 µg per slide; 3-24 h) retains weak canonical Wnt/β-catenin TCF/LEF signaling activity in HEK293 Luc-TCF/LEF cells on glass substrates, induces a significant increase in signaling at 3 h, and this signaling level is maintained until 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1242439-00-4
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分子量 1427.58
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分子式 C54H90N16O23S3
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配列
Ac-Cys-Asn-Lys-Thr-Ser-Glu-Gly-Met-Asp-Gly-Cys-Glu-Leu-NH2
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シーケンスの短縮
Ac-CNKTSEGMDGCEL-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
UM206_L 関連分類
HY-P11867 関連分類
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