Uplarafenib
Based on 1 Customer Validation
Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.63%
- CAS 番号: 1425485-87-5
- 分子式: C22H21F3N4O4S
- 分子量:494.49
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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生物活性
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BRAF-V600E < 50 nM (IC50) |
Braf 50-100 nM (IC50) |
Uplarafenib (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1].
Uplarafenib shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1].
Uplarafenib (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375, SK-MEL-28, SK-MEL-31 and CHL-1
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Concentration:
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Incubation Time:72 h
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Result:Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
化学情報
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CAS 番号 1425485-87-5
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性状 Solid
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分子量 494.49
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分子式 C22H21F3N4O4S
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Color Light yellow to yellow
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SMILES
O=C(C1=C(F)C(NS(=O)(CCC)=O)=CC(F)=C1F)C2=CC=C3N=CC(N4CCOCC4)=NC3=C2
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別名
B-Raf IN 10
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0223 mL | 10.1114 mL | 20.2229 mL | 50.5571 mL |
| 5 mM | 0.4045 mL | 2.0223 mL | 4.0446 mL | 10.1114 mL | |
| 10 mM | 0.2022 mL | 1.0111 mL | 2.0223 mL | 5.0557 mL | |
| 15 mM | 0.1348 mL | 0.6741 mL | 1.3482 mL | 3.3705 mL | |
| 20 mM | 0.1011 mL | 0.5056 mL | 1.0111 mL | 2.5279 mL | |
| 25 mM | 0.0809 mL | 0.4045 mL | 0.8089 mL | 2.0223 mL | |
| 30 mM | 0.0674 mL | 0.3370 mL | 0.6741 mL | 1.6852 mL | |
| 40 mM | 0.0506 mL | 0.2528 mL | 0.5056 mL | 1.2639 mL | |
| 50 mM | 0.0404 mL | 0.2022 mL | 0.4045 mL | 1.0111 mL | |
| 60 mM | 0.0337 mL | 0.1685 mL | 0.3370 mL | 0.8426 mL | |
| 80 mM | 0.0253 mL | 0.1264 mL | 0.2528 mL | 0.6320 mL | |
| 100 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5056 mL |
Uplarafenib 関連分類
HY-148059 関連分類
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