VCP171
Based on 1 Customer Validation
VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.18%
- CAS 番号: 1018830-99-3
- 分子式: C18H12F3NOS
- 分子量:347.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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A1R |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | ED50 |
15.8 μM
Compound: 6b
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Activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as agonist-receptor ternary complex remaining by [35S]GTPgammaS binding assay
Activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as agonist-receptor ternary complex remaining by [35S]GTPgammaS binding assay
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[PMID: 17980606] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neurons from male Sprague-Dawley rats (5-6 weeks; performed a partial nerve ligation (PNL) of the left sciatic nerve to create neuropathic pain model)[1]
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Dosage:10 μM
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Administration:0-30 min
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Result:Reduced AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in Lamina I cells in sham (13±2%, n=7 cells) and nerve-injured animals (24±4%, n=8 cells) compared with predrug controls; increased paired pulse ration in cells from sham control animals; was significantly more effective in Lamina II neurons from nerve-injured animals than sham controls.
化学情報
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CAS 番号 1018830-99-3
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性状 Solid
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分子量 347.35
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分子式 C18H12F3NOS
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Color Light yellow to yellow
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SMILES
O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC=C2)C3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (287.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8789 mL | 14.3947 mL | 28.7894 mL | 71.9735 mL |
| 5 mM | 0.5758 mL | 2.8789 mL | 5.7579 mL | 14.3947 mL | |
| 10 mM | 0.2879 mL | 1.4395 mL | 2.8789 mL | 7.1974 mL | |
| 15 mM | 0.1919 mL | 0.9596 mL | 1.9193 mL | 4.7982 mL | |
| 20 mM | 0.1439 mL | 0.7197 mL | 1.4395 mL | 3.5987 mL | |
| 25 mM | 0.1152 mL | 0.5758 mL | 1.1516 mL | 2.8789 mL | |
| 30 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3991 mL | |
| 40 mM | 0.0720 mL | 0.3599 mL | 0.7197 mL | 1.7993 mL | |
| 50 mM | 0.0576 mL | 0.2879 mL | 0.5758 mL | 1.4395 mL | |
| 60 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1996 mL | |
| 80 mM | 0.0360 mL | 0.1799 mL | 0.3599 mL | 0.8997 mL | |
| 100 mM | 0.0288 mL | 0.1439 mL | 0.2879 mL | 0.7197 mL |
VCP171 関連分類
HY-113608 関連分類
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