Vindesine
Based on 1 Customer Validation
Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin. Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.73%
- CAS 番号: 53643-48-4
- 分子式: C43H55N5O7
- 分子量:753.93
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Vindesine binds to intracellular tubulin, thereby inhibiting the assembly of functional microtubules in actively dividing cells[2].
Vindesine potently inhibits mitosis in cancer cell lines[3].
Vindesine inhibits the invasion of malignant cells into normal tissues in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 53643-48-4
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性状 Solid
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分子量 753.93
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分子式 C43H55N5O7
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Color White to off-white
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SMILES
CN([C@]1([H])[C@@]23[C@]4([H])[C@](C=CCN4CC3)(CC)[C@@H](O)[C@]1(O)C(N)=O)C(C2=C5)=CC(OC)=C5[C@](C[C@]6([H])C[N@]7C[C@@](CC)(O)C6)(C(OC)=O)C8=C(CC7)C9=CC=CC=C9N8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (132.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gökbuget N, et al. Vindesine in the treatment of leukaemia. Leuk Lymphoma. 1997;26(5-6):497-506. [Content Brief]
[2]. Sørensen JB, et al. Is there a role for vindesine in the treatment of non-small cell lung cancer?. Invest New Drugs. 1993;11(2-3):103-133. [Content Brief]
[3]. Dhyani P, et al. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22(1):206. Published 2022 Jun 2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3264 mL | 6.6319 mL | 13.2638 mL | 33.1596 mL |
| 5 mM | 0.2653 mL | 1.3264 mL | 2.6528 mL | 6.6319 mL | |
| 10 mM | 0.1326 mL | 0.6632 mL | 1.3264 mL | 3.3160 mL | |
| 15 mM | 0.0884 mL | 0.4421 mL | 0.8843 mL | 2.2106 mL | |
| 20 mM | 0.0663 mL | 0.3316 mL | 0.6632 mL | 1.6580 mL | |
| 25 mM | 0.0531 mL | 0.2653 mL | 0.5306 mL | 1.3264 mL | |
| 30 mM | 0.0442 mL | 0.2211 mL | 0.4421 mL | 1.1053 mL | |
| 40 mM | 0.0332 mL | 0.1658 mL | 0.3316 mL | 0.8290 mL | |
| 50 mM | 0.0265 mL | 0.1326 mL | 0.2653 mL | 0.6632 mL | |
| 60 mM | 0.0221 mL | 0.1105 mL | 0.2211 mL | 0.5527 mL | |
| 80 mM | 0.0166 mL | 0.0829 mL | 0.1658 mL | 0.4145 mL | |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1326 mL | 0.3316 mL |
Vindesine 関連分類
HY-16514 関連分類
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