Vindesine
Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin. Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 53643-48-4
- 分子式: C43H55N5O7
- 分子量:753.93
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Vindesine binds to intracellular tubulin, thereby inhibiting the assembly of functional microtubules in actively dividing cells[2].
Vindesine potently inhibits mitosis in cancer cell lines[3].
Vindesine inhibits the invasion of malignant cells into normal tissues in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 53643-48-4
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分子量 753.93
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分子式 C43H55N5O7
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SMILES
CN([C@]1([H])[C@@]23[C@]4([H])[C@](C=CCN4CC3)(CC)[C@@H](O)[C@]1(O)C(N)=O)C(C2=C5)=CC(OC)=C5[C@](C[C@]6([H])C[N@]7C[C@@](CC)(O)C6)(C(OC)=O)C8=C(CC7)C9=CC=CC=C9N8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gökbuget N, et al. Vindesine in the treatment of leukaemia. Leuk Lymphoma. 1997;26(5-6):497-506. [Content Brief]
[2]. Sørensen JB, et al. Is there a role for vindesine in the treatment of non-small cell lung cancer?. Invest New Drugs. 1993;11(2-3):103-133. [Content Brief]
[3]. Dhyani P, et al. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22(1):206. Published 2022 Jun 2. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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