VU6004256
Based on 1 Customer Validation
VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.61%
- CAS 番号: 2011034-33-4
- 分子式: C25H25F2N5O2
- 分子量:465.50
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
mAChR1 155 nM (EC50) |
体内実験
VU6004256 (3, 10 mg/kg; i.p.) reverses the performance impairments in novel object recognition and cue-mediated fear conditioning tasks and reduces hyper locomotor activity in NR1 KD mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Adult male NR1 KD mice[1]
-
Dosage:10 mg/kg
-
Administration:I.p.
-
Result:Showed no effect on pyramidal cell firing rate in WT littermate controls, significantly reduced pyramidal cell firing rate in NR1 KD mice.
-
Animal Model:Wild-type and NR1 KD mice[1]
-
Dosage:3, 10 mg/kg
-
Administration:I.p.
-
Result:Dose-dependently reduced locomotor activity in NR1 KD, but not in WT mice, resulted in dose-dependent increases in recognition index in WT and NR1 KD mice; improved performance on test day in cue-mediated conditioned freezing in NR1 KD but not WT mice.
化学情報
-
CAS 番号 2011034-33-4
-
性状 Solid
-
分子量 465.50
-
分子式 C25H25F2N5O2
-
Color White to off-white
-
SMILES
O=C(C1=CN(CC2=CC=C(C3=CN(C)N=C3)N=C2)C4=C1C(F)=CC(F)=C4)N[C@@H]5[C@@H](O)CCCC5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VU6004256 関連分類
HY-117408 関連分類
Powered by Bioz