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製品番号: HY-N19876

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WF-5239

WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 91224-36-1
分子式: C₉H₉NO₂
分子量:163.17

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

WF-5239 構造式

CAS 番号: 91224-36-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis^[1].

IC₅₀ & Target

^[1]

Fungal Metabolite

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体外実験

WF-5239 (2 minutes) potently inhibits Arachidonic acid (HY-109590)- and Collagen (HY-NP003)-induced aggregation in rabbit platelet-rich plasma, with IC₅₀ values of 1.25 μg/mL and 5.0 μg/mL respectively, and has no meaningful activity against ADP- or Thrombin (HY-114164)-induced aggregation^[1].
WF-5239 (100 μg/mL) exhibits no antimicrobial activity against yeasts, fungi, bacteria, or mycobacteria at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

WF-5239 (3-30 mg/kg; i.p.; single dose) improves survival in a mouse model of Arachidonic acid-induced pulmonary thrombosis, with 80% survival observed at 30 mg/kg ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY (male, 15~20 g, pulmonary thrombosis induced by sodium Arachidonic acid slow tail vein injection)^[1]
Dosage:

3 mg/kg; 10 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Increased survival rate to 80% in 10 treated mice at 30 mg/kg.
Increased survival rate to 40% in 10 treated mice at 10 mg/kg.
Increased survival rate to 10% in 10 treated mice at 3 mg/kg.

化学情報

CAS 番号 91224-36-1
分子量 163.17
分子式 C₉H₉NO₂
SMILES

O=CN/C=C\C1=CC=C(C=C1)O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Aspergillus fumigatus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Umehara K, et al. Studies on WF-5239, a new potent platelet aggregation inhibitor. J Antibiot (Tokyo). 1984;37(5):469-474. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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