WLBU2 acetate
Based on 1 Customer Validation
WLBU2 acetate is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 acetate exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 acetate prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 acetate can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- 分子式: C151H260N66O25·xC2H4O2
- 分子量:3400.11 (free base)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
生物活性
WLBU2 (5-90 μM, 24 h (abiotic surface); 10-100 μM, 5 h (CFAECs)) acetate prevents abiotic P. aeruginosa biofilms on an abiotic surface and on human cystic fibrosis airway epithelial cells (CFAECs)[1].
WLBU2 (50 μM, 5 h) acetate retains biofilm prevention activity in high salt (100 mM Nacl) and low pH (6.5-7.0) environments in CFAECs[1].
WLBU2 (20 μM, 5 h) acetate shows synergistic effect when combined with Tobramycin (HY-B0441), ciprofloxacin (HY-B0356), Ceftazidime (HY-B0593), and Meropenem (HY-13678), but has no synergistic effect with Colistin (HY-113678) in CFAECs[1].
WLBU2 acetate exhibits a MIC value of 7.943 μM against Klebsiella pneumoniae and a MIC value of 7.484 μM against clinical isolates of Acinetobacter baumannii, with the MBC values of the bacterial isolates being identical to their respective MIC values, indicating its bactericidal effect[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 3400.11 (free base)
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分子式 C151H260N66O25·xC2H4O2
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Color White to off-white
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配列
Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg
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シーケンスの短縮
RRWVRRVRRWVRRVVRVVRRWVRR
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)