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製品番号: HY-162002

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WSD0628

Name: WSD0628
Brand: MedChemExpress
SKU: HY-162002
Price: 510.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.43%
CAS 番号: 2765448-96-0
分子式: C₂₃H₂₃F₂N₅O₂
分子量:439.46

保管条件:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

WSD0628 構造式

CAS 番号: 2765448-96-0

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect^[1].

ATM/ATR アイソフォーム固有の製品をすべて表示 :

体外実験

WSD0628 significantly increased the radiosensitivity of U251 cells in clonogenic survival assays (0 nM vs. 30 nM at 5Gy, p<0.01)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

WSD0628 (10 mg/kg, a single dose of 12.5 Gy combined) has profound impact on treatment efficacy in the melanoma brain metastasis M12 PDX^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2765448-96-0
性状 Solid
分子量 439.46
分子式 C₂₃H₂₃F₂N₅O₂
Color Off-white to light yellow
SMILES

CN(C(N1[C@H]2C(F)(F)CN(C)CC2)=O)C3=C1C4=CC(C5=CN=C(OC)C=C5)=CC=C4N=C3
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhiyi Xue, et al. Abstract A148: The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenografts. Mol Cancer Ther (2023) 22 (12_Supplement): A148.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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