XF067-68
Based on 1 Customer Validation
XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases.
(Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-173627); Black: linker (HY-Y0966)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.56%
- CAS 番号: 2407452-79-1
- 分子式: C52H59F4N9O7S
- 分子量:1030.14
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Anti-Cancer Compound Library
HY-L025
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Heterocyclic Compound Library
HY-L138
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PROTAC Library
HY-L151
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
WDR5[1]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2407452-79-1
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性状 Solid
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分子量 1030.14
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分子式 C52H59F4N9O7S
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Color White to off-white
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SMILES
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (97.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9707 mL | 4.8537 mL | 9.7074 mL | 24.2685 mL |
| 5 mM | 0.1941 mL | 0.9707 mL | 1.9415 mL | 4.8537 mL | |
| 10 mM | 0.0971 mL | 0.4854 mL | 0.9707 mL | 2.4269 mL | |
| 15 mM | 0.0647 mL | 0.3236 mL | 0.6472 mL | 1.6179 mL | |
| 20 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2134 mL | |
| 25 mM | 0.0388 mL | 0.1941 mL | 0.3883 mL | 0.9707 mL | |
| 30 mM | 0.0324 mL | 0.1618 mL | 0.3236 mL | 0.8090 mL | |
| 40 mM | 0.0243 mL | 0.1213 mL | 0.2427 mL | 0.6067 mL | |
| 50 mM | 0.0194 mL | 0.0971 mL | 0.1941 mL | 0.4854 mL | |
| 60 mM | 0.0162 mL | 0.0809 mL | 0.1618 mL | 0.4045 mL | |
| 80 mM | 0.0121 mL | 0.0607 mL | 0.1213 mL | 0.3034 mL |
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