YTP-17
Based on 1 Customer Validation
YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. YTP-17 shows anti-tumor efficacy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.04%
- CAS 番号: 2714433-21-1
- 分子式: C26H25ClF2N2O4
- 分子量:502.94
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
YAP アイソフォーム固有の製品をすべて表示
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生物活性
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YAP/TAZ-TEAD |
YTP-17 shows antiproliferative activity against NCI-H2052 cells with an IC50 of 45 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SCID mice bearing NCI-H226 cells[1]
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Dosage:60 mg/kg, 10 mL/kg
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Administration:Oral gavage; once daily; for 2 weeks
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Result:A 45% reduction in tumor volume.
化学情報
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CAS 番号 2714433-21-1
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性状 Solid
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分子量 502.94
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分子式 C26H25ClF2N2O4
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Color White to off-white
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SMILES
FC1=CC2=C([C@@]([C@@]3=C(C=CC(OCCO)=C3F)C(NC)=O)=C1Cl)C[C@](C4=CC=CC=C4)(CNC)O2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (198.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9883 mL | 9.9415 mL | 19.8831 mL | 49.7077 mL |
| 5 mM | 0.3977 mL | 1.9883 mL | 3.9766 mL | 9.9415 mL | |
| 10 mM | 0.1988 mL | 0.9942 mL | 1.9883 mL | 4.9708 mL | |
| 15 mM | 0.1326 mL | 0.6628 mL | 1.3255 mL | 3.3138 mL | |
| 20 mM | 0.0994 mL | 0.4971 mL | 0.9942 mL | 2.4854 mL | |
| 25 mM | 0.0795 mL | 0.3977 mL | 0.7953 mL | 1.9883 mL | |
| 30 mM | 0.0663 mL | 0.3314 mL | 0.6628 mL | 1.6569 mL | |
| 40 mM | 0.0497 mL | 0.2485 mL | 0.4971 mL | 1.2427 mL | |
| 50 mM | 0.0398 mL | 0.1988 mL | 0.3977 mL | 0.9942 mL | |
| 60 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8285 mL | |
| 80 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.6213 mL | |
| 100 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4971 mL |
YTP-17 関連分類
HY-150256 関連分類
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