ZK164015
Based on 1 Customer Validation
ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 177583-70-9
- 分子式: C30H43NO4S
- 分子量:513.73
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cancer cell lines | IC50 |
0.02 μM
Compound: ZK-164015
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Inhibition of 10e-9 M E2 stimulated transcriptional activation in ER+MCF-7/2a breast cancer cells
Inhibition of 10e-9 M E2 stimulated transcriptional activation in ER+MCF-7/2a breast cancer cells
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[PMID: 15324884] |
| Cancer cell lines | IC50 |
0.05 μM
Compound: ZK-164015
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Inhibition of 10e-9 M E2 stimulated MCF-7 breast cancer cell proliferation
Inhibition of 10e-9 M E2 stimulated MCF-7 breast cancer cell proliferation
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[PMID: 15324884] |
| Cancer cell lines | IC50 |
1.4 nM
Compound: ZK-164015
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Inhibition of ER-MDA-MB 231 breast cancer cell proliferation over 200 hr
Inhibition of ER-MDA-MB 231 breast cancer cell proliferation over 200 hr
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[PMID: 15324884] |
化学情報
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CAS 番号 177583-70-9
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性状 Solid
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分子量 513.73
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分子式 C30H43NO4S
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Color Off-white to light yellow
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SMILES
OC1=CC2=C(N(CCCCCCCCCCS(=O)(CCCCC)=O)C(C3=CC=C(O)C=C3)=C2C)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (194.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9465 mL | 9.7327 mL | 19.4655 mL | 48.6637 mL |
| 5 mM | 0.3893 mL | 1.9465 mL | 3.8931 mL | 9.7327 mL | |
| 10 mM | 0.1947 mL | 0.9733 mL | 1.9465 mL | 4.8664 mL | |
| 15 mM | 0.1298 mL | 0.6488 mL | 1.2977 mL | 3.2442 mL | |
| 20 mM | 0.0973 mL | 0.4866 mL | 0.9733 mL | 2.4332 mL | |
| 25 mM | 0.0779 mL | 0.3893 mL | 0.7786 mL | 1.9465 mL | |
| 30 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL | |
| 40 mM | 0.0487 mL | 0.2433 mL | 0.4866 mL | 1.2166 mL | |
| 50 mM | 0.0389 mL | 0.1947 mL | 0.3893 mL | 0.9733 mL | |
| 60 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8111 mL | |
| 80 mM | 0.0243 mL | 0.1217 mL | 0.2433 mL | 0.6083 mL | |
| 100 mM | 0.0195 mL | 0.0973 mL | 0.1947 mL | 0.4866 mL |
ZK164015 関連分類
HY-103455 関連分類
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