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Cat. No.: HY-110133R

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JTE-607 (Standard)

JTE-607 (Standard) is the analytical standard of JTE-607 (HY-110133). This product is intended for research and analytical applications. JTE-607, a highly selective inflammatory cytoK_ine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytoK_ine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607.

For research use only. We do not sell to patients.

CAS No.: 188791-09-5
Formula: C₂₅H₃₃Cl₄N₃O₅
Molecular Weight:597.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JTE-607 (Standard) Chemical Structure

CAS No.: 188791-09-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 188791-09-5
Molecular Weight 597.36
Formula C₂₅H₃₃Cl₄N₃O₅
SMILES

CCOC([C@H](CC1=CC=CC=C1)NC(C2=C(C(Cl)=C(C(Cl)=C2)OCCN3CCN(CC3)C)O)=O)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. M Kakutani, et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8. [Content Brief]

[2]. Nathan T Ross, et al. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. Nat Chem Biol. 2020 Jan;16(1):50-59. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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