KF20274
KF20274 is an orally active adenosine A1 receptor antagonist. KF20274 increases the fecal pellet output in rats, and does not affect small intestinal propulsion or gastric emptying at defecation-increasing doses. KF20274 does not induce diarrhea at defecation-increasing doses. KF20274 can be used for the research of constipation.
For research use only. We do not sell to patients.
- CAS No.: 143394-68-7
- Formula: C21H29N5O
- Molecular Weight:367.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Adenosine Receptor Isoforms
More
Biological Activity
|
A1AR |
KF20274 (0.01-3 mg/kg; p.o.) does not alter small intestinal propulsion, gastric emptying in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Sprague-Dawley (male, 150-250 g)[1]
-
Dosage:0.0003, 0.001, 0.003, 0.01, 0.03 mg/kg
-
Administration:p.o.
-
Result:Increased fecal wet weight and dry weight.
Maintained fecal water content at 51-55%.
Resulted in 0/10 incidence of diarrhea across all tested doses.
Chemical Information
-
CAS No. 143394-68-7
-
Molecular Weight 367.49
-
Formula C21H29N5O
-
SMILES
CCCN1C2=C(C3=N[C@H](CC)CN3C1=O)NC(C45C6CC(CC(C6)C5)C4)=N2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KF20274 Related Classifications
HY-182340 Related Classifications
Powered by Bioz