2. Cell Cycle/DNA Damage
  3. CDK
  4. KGA-4066

KGA-4066 is a novel non-ATP-competitive CDK2 inhibitor. KGA-4066 inhibits CDK2/Cyclin A2 with an IC50 value of 236.7 nM, disrupts their interaction, promots CDK2 degradation via the lysosomal pathway. KGA-4066 has anticancer activity against hepatocellular carcinoma.

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KGA-4066

KGA-4066 Chemical Structure

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KGA-4066 Related Antibodies

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Description

KGA-4066 is a novel non-ATP-competitive CDK2 inhibitor. KGA-4066 inhibits CDK2/Cyclin A2 with an IC50 value of 236.7 nM, disrupts their interaction, promots CDK2 degradation via the lysosomal pathway. KGA-4066 has anticancer activity against hepatocellular carcinoma[1].

IC50 & Target

IC50: 236.7 nM (CDK2/Cyclin A2)[1]
Molecular Weight

513.06

Formula

C30H37ClO5
SMILES

C[C@]1(O)CC[C@@H]2[C@H](OC(C2=C)=O)C3=C1[C@H]4C[C@]3(C)[C@]([C@H]5[C@H](O6)C7C(CC[C@@H](Cl)[C@]7(C)CC5)=C)(C4)C6=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KGA-4066 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KGA-4066KGA4066KGA 4066CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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