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Cat. No.: HY-161326

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CXF-007

CXF-007 is a potent and specific FGFR4 inhibitor with a IC₅₀ value of 7 nM. CXF-007 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2727083-99-8
Formula: C₃₄H₃₃N₇O₅
Molecular Weight:619.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CXF-007 Chemical Structure

CAS No.: 2727083-99-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CXF-007 is a potent and specific FGFR4 inhibitor with a IC₅₀ value of 7 nM. CXF-007 has antitumor activity^[1].

IC₅₀ & Target

FGFR4

7 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>5000 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	1 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	170 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	445 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	530 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
HCC1937	IC₅₀	3.36 μM Compound: CXF-007	Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Hep 3B2	IC₅₀	0.77 μM Compound: CXF-007	Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Huh-7	IC₅₀	1.16 μM Compound: CXF-007	Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
MDA-MB-453	IC₅₀	0.37 μM Compound: CXF-007	Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
NCI-H1299	IC₅₀	>10 μM Compound: CXF-007	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK8 assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK8 assay	[PMID: 38432058]

Chemical Information

CAS No. 2727083-99-8
Molecular Weight 619.67
Formula C₃₄H₃₃N₇O₅
SMILES

COC1=CC(OC)=CC(N(C2)C(N(CCC3=CC=C(NC(C=C)=O)C=C3)C4=C2C=NC(NC5=C(NC(C=C)=O)C=CC=C5)=N4)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4. Eur J Med Chem. 2024 Feb 28;268:116281. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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