TPC-144
TPC-144 is a LSD1/KDM1A inhibitor. TPC-144 inhibits LSD1, and leads to a decrease in the protein level of DNMT1, causing low methylation of the LINE-1 element. TPC-144 can also produce a synergistic effect with Decitabine (HY-A0004) (a DNMT inhibitor), jointly promoting DNA demethylation and thereby inducing differentiation and apoptosis of leukemia cells. TPC-144 has also demonstrated anti-tumor efficacy in acute myeloid leukemia (AML) models. TPC-144 can be used for the study of AML.
For research use only. We do not sell to patients.
- CAS No.: 2098621-17-9
- Formula: C31H31F2N3O2
- Molecular Weight:515.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 2098621-17-9
-
Molecular Weight 515.59
-
Formula C31H31F2N3O2
-
SMILES
N[C@H]1C[C@H]2CC[C@@H](C1)N2C(C3=CC(C4=CC=C(C(F)=C4)C#N)=C(C=C3)C5=CC=C(C=C5F)CC(O)(C)C)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TPC-144 Related Classifications
HY-123577 Related Classifications
Powered by Bioz