4-MeO-MiPT
4-MeO-MiPT is a serotonin transporter (SERT) inhibitor and serotonin 2A receptor (5-HT2A) agonist with pIC50 and IC50 values of 57 nM and 0.43 nM for human SERT, and pEC50 and EC50 values of 23 nM and 2.3 nM for human 5-HT2A, respectively. 4-MeO-MiPT blocks serotonin uptake via SERT, acts as an agonist at 5-HT2A receptors, and exhibits agonist activity at 5-HT1A, 5-HT1D, 5-HT2B, and 5-HT2C receptors. 4-MeO-MiPT can be used for the research of depression.
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- CAS No.: 96096-53-6
- 화학식: C15H22N2O
- 분자량:246.35
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
5-HT2A Receptor 23 nM (EC50) |
5-HT2A Receptor 2.3 nM (pEC50) |
In Vitro
4-MeO-MiPT displays nanomolar affinity for multiple serotonin receptor subtypes, SERT, alpha2-adrenergic receptors, and sigma-2 receptors[1].
4-MeO-MiPT is a full agonist at human 5-HT2A receptors and a partial agonist at human 5-HT2B and 5-HT2C receptors, with highest potency at human 5-HT2A and 5-HT2B receptors[1].
4-MeO-MiPT potently inhibits serotonin uptake via SERT in rat brain synaptosomes with an IC50 of 57 nM, and has no meaningful activity at DAT or NET[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male and female, 8 weeks of age)[1]
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Dosage:0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 10 mg/kg; 30 mg/kg
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Administration:s.c.; single dose
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Result:Induced a dose-dependent increase in HTR counts, with an ED50 of 0.97 mg/kg and a maximal efficacy of 39 HTRs per 30 minutes.
Increased HTR counts relative to 30 mg/kg 4-MeO-MiPT alone when preceded by 3 mg/kg WAY100635 (HY-10349) pretreatment.
Chemical Information
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CAS No. 96096-53-6
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분자량 246.35
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화학식 C15H22N2O
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SMILES
COC1=C2C(CCN(C(C)C)C)=CNC2=CC=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-MeO-MiPT Related Classifications
HY-W682464 Related Classifications
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