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Cat. No.: HY-156562B

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5-PT TFA

(Synonyms: 5-Propargyltryptamide TFA)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

5-PT (5-Propargyltryptamide) TFA is an alkyne-functionalized derivative of 5-HT (HY-B1473A) and serotonylation substrate that can be taken up by living cells. After conjugation with biotin, 5-PT TFA enables the identification of serotonylated proteins via copper click chemistry and mass spectrometry. 5-PT TFA can label and isolate serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT TFA is applicable to research related to bronchopulmonary dysplasia.

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CAS No.: 3117303-22-4
화학식: C₁₅H₁₅F₃N₂O₃
분자량:328.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

5-PT TFA Chemical Structure

CAS No.: 3117303-22-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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In Vitro

5-PT (100 μM; 24 h) TFA labels 121 unique serotonylated proteins in MLE-12 alveolar epithelial cells, with many of these proteins linked to cellular processes and cell behavior regulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3117303-22-4
분자량 328.29
화학식 C₁₅H₁₅F₃N₂O₃
SMILES

O=C(C(F)(F)F)O.C#CCOC1=CC2=C(NC=C2CCN)C=C1
Synonyms

5-Propargyltryptamide TFA
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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iScience

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. [Abstract]

2025 Nov 19;28(12):114120. PMID: 41438086

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Handling Instructions (2659 KB)

References

[1]. Cai P, Ding R, Yin C, et al.. 5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. iScience. 2025 Dec 19;28(12):114120. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Publications (1)
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5-PT TFA

Publications Citing Use of MedChemExpress (MCE) 5-PT TFA