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Cat. No.: HY-111653

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CycLuc1

Name: CycLuc1
Brand: MedChemExpress
SKU: HY-111653
Price: 50.00 USD
Availability: InStock
Rating: 5 (4 reviews)

4 Cited Publications

고객리뷰

Based on 4 publication(s) in Google Scholar

CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.09%
CAS No.: 1247879-16-8
화학식: C₁₃H₁₁N₃O₂S₂
분자량:305.38

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

CycLuc1 Chemical Structure

CAS No.: 1247879-16-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (4)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Luciferase^[1]

In Vivo

CycLuc1 (0.05-5 mM, intraperitoneally injected) can improve bioluminescence imaging (BLI) of the existing luciferase reporter protein in mice and achieve brain imaging that D-luciferin cannot achieve^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse xenograft tumor models^[2]
Dosage:

0.05, 0.5, 1, 5 mM, 100 μL
Administration:

i.p.
Result:

Yielded a >10-fold higher bioluminescent signal than could be obtained from D-luciferin injection at equivalent doses.

Related Protocols :

Bioluminescent/Fluorescent Imaging Xenograft

Chemical Information

CAS No. 1247879-16-8
Appearance Solid
분자량 305.38
화학식 C₁₃H₁₁N₃O₂S₂
Color Yellow to brown
SMILES

O=C([C@@H]1N=C(C2=NC3=CC4=C(NCC4)C=C3S2)SC1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

All Bio/Physico-chemical AssayIn Vivo Imaging

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Journal Impact Factor

Sci Rep

Real-time bioluminescence imaging of mycobacteria with Akaluc: a novel method for monitoring drug efficacy. [Abstract]

2026 May 15;16(1):15193. PMID: 42151204
Microbiol Spectr

Near-infrared in vivo imaging system for dynamic visualization of lung-colonizing bacteria in mouse pneumonia. [Abstract]

2024 Nov 5;12(11):e0082824. PMID: 39287455

CycLuc1 purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2024 Nov 5;12(11):e0082824. [Abstract]

The luminescence signals of the ATCC 17978-Luc strain with CycLuc1 (10 μM) was 9.0 × 10⁵ RLU.
Res Sq

2026 Aug 27:rs.3.rs-10755545. PMID: 42687893
bioRxiv

2023 Apr 29.

CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

CycLuc1 (5 mM, 10 μL/g) injection improved signal detection in the head in CAG-LSL-oFluc mice.

CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

RLU of the tissue extracts of oFluc from C57BL/6 mice supplemented with CycLuc1 (1 mM).

용액&용해도

In Vitro:

DMSO : 50 mg/mL (163.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2746 mL

16.3730 mL

32.7461 mL

5 mM

0.6549 mL

3.2746 mL

6.5492 mL

10 mM

0.3275 mL

1.6373 mL

3.2746 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shiv K, et al. Abstract 4112: Synthetic luciferin, CycLuc1, improves bioluminescence imaging for intracranial glioblastoma xenografts. 10.1158/1538-7445.AM2018-4112

[2]. Evans MS, et al. A synthetic luciferin improves bioluminescence imaging in live mice. Nat Methods. 2014 Apr;11(4):393-5. doi: 10.1038/nmeth.2839. Epub 2014 Feb 9. Erratum in: Nat Methods. 2014 Apr;11(4):395. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2746 mL	16.3730 mL	32.7461 mL	81.8652 mL
	5 mM	0.6549 mL	3.2746 mL	6.5492 mL	16.3730 mL
	10 mM	0.3275 mL	1.6373 mL	3.2746 mL	8.1865 mL
	15 mM	0.2183 mL	1.0915 mL	2.1831 mL	5.4577 mL
	20 mM	0.1637 mL	0.8187 mL	1.6373 mL	4.0933 mL
	25 mM	0.1310 mL	0.6549 mL	1.3098 mL	3.2746 mL
	30 mM	0.1092 mL	0.5458 mL	1.0915 mL	2.7288 mL
	40 mM	0.0819 mL	0.4093 mL	0.8187 mL	2.0466 mL
	50 mM	0.0655 mL	0.3275 mL	0.6549 mL	1.6373 mL
	60 mM	0.0546 mL	0.2729 mL	0.5458 mL	1.3644 mL
	80 mM	0.0409 mL	0.2047 mL	0.4093 mL	1.0233 mL
	100 mM	0.0327 mL	0.1637 mL	0.3275 mL	0.8187 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (4)
용액&용해도
- In Vitro
순도&문서
References

1/16
1/16

CycLuc1 purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2024 Nov 5;12(11):e0082824. [Abstract]

Customer Validation
The luminescence signals of the ATCC 17978-Luc strain with CycLuc1 (10 μM) was 9.0 × 10⁵ RLU.
1/16

CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

Customer Validation
CycLuc1 (5 mM, 10 μL/g) injection improved signal detection in the head in CAG-LSL-oFluc mice.
1/16

CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

Customer Validation
RLU of the tissue extracts of oFluc from C57BL/6 mice supplemented with CycLuc1 (1 mM).

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수량:
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CycLuc1

Publications Citing Use of MedChemExpress (MCE) CycLuc1