Fosfructose trisodium
Based on 1 publication(s) in Google Scholar
Fosfructose trisodium (Diphosphofructose trisodium, Esafosfan trisodium, FDP trisodium) is a cytoprotective natural sugar phosphate used in research on cardiovascular ischemia, sickle cell anemia, and asthma. Fosfructose trisodium acts by stimulating anaerobic glycolysis, which produces adenosine triphosphate under ischemic conditions.
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- Purity: 98.0%
- CAS No.: 38099-82-0
- 화학식: C6H11Na3O12P2
- 분자량:406.06
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Fosfructose trisodium
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Fosfructose trisodium (50-200 mg/g; oral; continuous feeding in artificial diet) enhances glycolysis in Hyphantria cunea larvae, induces 100% corrected mortality at doses of 50, 100, and 200 mg/g with dose-dependent speed, restricts larval growth and development, and disrupts chitin biosynthesis by altering pathway gene expression and tissue chitin levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:native stock pig (female, 8-10 weeks old, hypothermic circulatory arrest-induced organ injury model)[1]
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Dosage:500 mg/kg (before hypothermic circulatory arrest); 500 mg/kg (after hypothermic circulatory arrest)
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Administration:i.v.; 15-minute infusion (before hypothermic circulatory arrest); 30-minute infusion (after hypothermic circulatory arrest)
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Result:Achieved an 83.3% 7‑day survival rate.
Elevated venous phosphate and sodium levels, blood osmolarity, and improved postoperative fluid balance, while significantly reducing venous ionized calcium.
Decreased intracranial pressure, venous CK‑MB levels (at 30 min), and brain lactate‑pyruvate ratio (at the end).
Lowered total brain histopathologic scores, including thalamic and hippocampal injury, cortical edema, and dark/eosinophilic neurons (total and thalamic).
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Animal Model:Lepidoptera: Arctiidae larvae (3rd and 5th instar, reared under controlled laboratory conditions)[2]
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Dosage:50 mg/g; 100 mg/g; 200 mg/g
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Administration:p.o.; continuous feeding in artificial diet
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Result:Resulted in 100% corrected mortality, reduced larval weight, food intake, pupation rate and pupal weight and delayed molting.
Enhanced HK, PFK, PK activities, upregulated HcHK2, HcPFK, HcPK, HcTre1, HcCHSB, decreased glucose and increased pyruvate levels in midgut and fat body, downregulated HcGNA, HcPAGM, HcUAP, HcCHSA, reduced epidermal chitin content, and increased midgut chitin content.
Chemical Information
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CAS No. 38099-82-0
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Appearance Solid
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분자량 406.06
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화학식 C6H11Na3O12P2
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Color White to off-white
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SMILES
O[C@H](C(COP(O)(O[Na])=O)=O)[C@@H]([C@@H](COP(O[Na])(O[Na])=O)O)O
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Synonyms
Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells. [Abstract]2026 Apr 22:e22570. PMID: 42018132
용액&용해도
H2O : 150 mg/mL (369.40 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (246.27 mM); Clear solution; Need ultrasonic
순도&문서
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Data Sheet (275 KB)
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Handling Instructions (2659 KB)
References
[1]. Romsi P, et al. Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs. J Thorac Cardiovasc Surg. 2003;125(3):686-698. [Content Brief]
[2]. Zhang S, et al. FDP-Na-induced enhancement of glycolysis impacts larval growth and development and chitin biosynthesis in fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae). Pestic Biochem Physiol. 2023;195:105560. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4627 mL | 12.3135 mL | 24.6269 mL | 61.5673 mL |
| 5 mM | 0.4925 mL | 2.4627 mL | 4.9254 mL | 12.3135 mL | |
| 10 mM | 0.2463 mL | 1.2313 mL | 2.4627 mL | 6.1567 mL | |
| 15 mM | 0.1642 mL | 0.8209 mL | 1.6418 mL | 4.1045 mL | |
| 20 mM | 0.1231 mL | 0.6157 mL | 1.2313 mL | 3.0784 mL | |
| 25 mM | 0.0985 mL | 0.4925 mL | 0.9851 mL | 2.4627 mL | |
| 30 mM | 0.0821 mL | 0.4104 mL | 0.8209 mL | 2.0522 mL | |
| 40 mM | 0.0616 mL | 0.3078 mL | 0.6157 mL | 1.5392 mL | |
| 50 mM | 0.0493 mL | 0.2463 mL | 0.4925 mL | 1.2313 mL | |
| 60 mM | 0.0410 mL | 0.2052 mL | 0.4104 mL | 1.0261 mL | |
| 80 mM | 0.0308 mL | 0.1539 mL | 0.3078 mL | 0.7696 mL | |
| 100 mM | 0.0246 mL | 0.1231 mL | 0.2463 mL | 0.6157 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fosfructose trisodium Related Classifications
HY-106950A Related Classifications
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