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GSK2837808A

47 Cited Publications
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Based on 47 publication(s) in Google Scholar

GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.

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  • Purity: 99.24%
  • CAS No.: 1445879-21-9
  • 화학식: C31H25F2N5O7S
  • 분자량:649.62
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • GSK2837808A Chemical Structure
    GSK2837808A Chemical Structure
  • Experimental Validation Results for GSK2837808A
  • Experimental Validation Results for GSK2837808A
  • Experimental Validation Results for GSK2837808A
  • Experimental Validation Results for GSK2837808A
  • Experimental Validation Results for GSK2837808A
CAS No.: 1445879-21-9
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  • GSK2837808A Chemical Structure
    GSK2837808A Chemical Structure
    1/16
  • 1/16

    GSK2837808A purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Apr 1;37(4):903-919.e10. [Abstract]

    Customer Validation
     FACS quantification of STAR-based CSC percentage in TPO3 and TPO4 treated with LDHA inhibitor GSK2837808A (GSK, 100 µM, 3 days).

  • 1/16

    GSK2837808A purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2024 Jan 24:S0016-5085(24)00064-7. [Abstract]

    Customer Validation
     Phase-contrast images of dysplastic organoids treated with dimethyl sulfoxide (DMSO; vehicle), GSK2837808A (LDH inhibitor; 10 μM), 6-aminonicotinamide (G6PD inhibitor; 50 μM), telaglenastat (GLS1 inhibitor; 1 μM) for 3 days.

  • 1/16

    GSK2837808A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2023 May 23:308:116271. [Abstract]

    Customer Validation
     The conditioned media (CM) from hypoxia-treated NRK-52 E cells reduce the expression of FN, COL-Ⅰ, α-SMA and PCNA proteins in NRK-49 F cells after SSR (Shen Shuai II Recipe) and (or) GSK (GSK2837808A) treatment.

  • 1/16

    GSK2837808A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Jun 22;11(1):3162. [Abstract]

    Customer Validation
     Proliferation of HepG2 cells with HULC knockdown (left panel) or overexpression (right panel) was measured with a CCK8 assay. For rescue experiments, HepG2-HULC cells were treated by FGFR1 inhibitor PD 166866 (2.5 μM), PKM2 activator DASA-58 (30 μM), or LDHA inhibitor GSK2837808A (10 μM), respectively.

  • 1/16

    GSK2837808A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Jul 9;11(1):3427. [Abstract]

    Customer Validation
     Chondrocytes were treated with IL-1β (10 ng/mL) in the presence of GSK2837808A (10 μM), oxamate (10 mM) or FX11 (40 μM) for 24 hours for supernatant lactic acid measurement.

  • GSK2837808A