K-Ras G12C-IN-1
Based on 1 publication(s) in Google Scholar
K-Ras G12C-IN-1 is an irreversible covalent KRAS G12C inhibitor. K-Ras G12C-IN-1 contains an electrophilic group that forms an irreversible covalent bond with Cys12 of mutant K-Ras. After covalent binding to Cys12, it locks Switch II in an inactive state and interferes with downstream Ras signaling. K-Ras G12C-IN-1 can be used in research related to pancreatic cancer, colon cancer, MYH-associated polyposis, colorectal cancer, and lung cancer.
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- Purity: 98.19%
- CAS No.: 1629265-17-3
- 화학식: C22H23Cl2N3O3
- 분자량:448.34
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) K-Ras G12C-IN-1
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Biological Activity
제품 설명
In Vitro
K-Ras G12C-IN-1 (Compound I-47) (3-100 μM) exhibits concentration-dependent cellular efficacy in MIA PaCa-2, NCI-H441 and NCI-H1568 cells, with MIA PaCa-2 cells showing a stronger response at most tested concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1629265-17-3
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Appearance Solid
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분자량 448.34
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화학식 C22H23Cl2N3O3
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Color White to off-white
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SMILES
ClC(C=C(OC)C(NCC(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC=CC=C3Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
2026 Feb 11:S2451-9456(26)00027-9. PMID: 41679298
용액&용해도
In Vitro:
DMSO : ≥ 40 mg/mL (89.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2305 mL | 11.1523 mL | 22.3045 mL | 55.7613 mL |
| 5 mM | 0.4461 mL | 2.2305 mL | 4.4609 mL | 11.1523 mL | |
| 10 mM | 0.2230 mL | 1.1152 mL | 2.2305 mL | 5.5761 mL | |
| 15 mM | 0.1487 mL | 0.7435 mL | 1.4870 mL | 3.7174 mL | |
| 20 mM | 0.1115 mL | 0.5576 mL | 1.1152 mL | 2.7881 mL | |
| 25 mM | 0.0892 mL | 0.4461 mL | 0.8922 mL | 2.2305 mL | |
| 30 mM | 0.0743 mL | 0.3717 mL | 0.7435 mL | 1.8587 mL | |
| 40 mM | 0.0558 mL | 0.2788 mL | 0.5576 mL | 1.3940 mL | |
| 50 mM | 0.0446 mL | 0.2230 mL | 0.4461 mL | 1.1152 mL | |
| 60 mM | 0.0372 mL | 0.1859 mL | 0.3717 mL | 0.9294 mL | |
| 80 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.6970 mL |
K-Ras G12C-IN-1 Related Classifications
HY-18604 Related Classifications
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