Valerylcarnitine
Based on 2 publication(s) in Google Scholar
Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines. Valerylcarnitine acts as a metabolomic biomarker for ionizing radiation exposure in nonhuman primates. Valerylcarnitine can be used for the research of type 1 diabetes.
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- Purity: 95.0%
- CAS No.: 40225-14-7
- 화학식: C12H23NO4
- 분자량:245.32
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Natural Product Library
HY-L021
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Human Endogenous Metabolite Compound Library
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Anti-diabetic Compound Library
HY-L040
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Natural Product and Natural Product-Like Compound Library
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Publications Citing Use of MedChemExpress (MCE) Valerylcarnitine
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
Chemical Information
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CAS No. 40225-14-7
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Appearance Solid
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분자량 245.32
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화학식 C12H23NO4
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Color White to off-white
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SMILES
CCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Adv
Remodeling of metabolism and inflammation by exercise ameliorates tumor-associated anemia. [Abstract]2021 Sep 10;7(37):eabi4852. PMID: 34516881
용액&용해도
H2O : 250 mg/mL (1019.08 mM; Need ultrasonic)
DMSO : 33.33 mg/mL (135.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.19 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.19 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (407.63 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (285 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Pannkuk EL, et al. Targeted Metabolomics of Nonhuman Primate Serum after Exposure to Ionizing Radiation: Potential Tools for High-throughput Biodosimetry. RSC Adv. 2016;6(56):51192-51202. [Content Brief]
[2]. Tuerxunyiming M, et al. LC-MS-based conventional metabolomics combined with machine learning models to identify metabolic markers for the diagnosis of type I diabetes. Front Endocrinol (Lausanne). 2025;16:1588718. Published 2025 Aug 7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 4.0763 mL | 20.3815 mL | 40.7631 mL | 101.9077 mL |
| 5 mM | 0.8153 mL | 4.0763 mL | 8.1526 mL | 20.3815 mL | |
| 10 mM | 0.4076 mL | 2.0382 mL | 4.0763 mL | 10.1908 mL | |
| 15 mM | 0.2718 mL | 1.3588 mL | 2.7175 mL | 6.7938 mL | |
| 20 mM | 0.2038 mL | 1.0191 mL | 2.0382 mL | 5.0954 mL | |
| 25 mM | 0.1631 mL | 0.8153 mL | 1.6305 mL | 4.0763 mL | |
| 30 mM | 0.1359 mL | 0.6794 mL | 1.3588 mL | 3.3969 mL | |
| 40 mM | 0.1019 mL | 0.5095 mL | 1.0191 mL | 2.5477 mL | |
| 50 mM | 0.0815 mL | 0.4076 mL | 0.8153 mL | 2.0382 mL | |
| 60 mM | 0.0679 mL | 0.3397 mL | 0.6794 mL | 1.6985 mL | |
| 80 mM | 0.0510 mL | 0.2548 mL | 0.5095 mL | 1.2738 mL | |
| 100 mM | 0.0408 mL | 0.2038 mL | 0.4076 mL | 1.0191 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Valerylcarnitine Related Classifications
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