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Cat. No.: HY-184588

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AB13-08

AB13-08 is a selective dopamine receptor agonist with a K_i value of 53.9 nM for human D₃R. AB13-08 is applicable to the research of neurological disorders such as Parkinson's disease and schizophrenia.

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화학식: C₂₄H₃₁N₇O₂
분자량:449.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AB13-08 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Human D₃ Receptor

53.9 nM (Ki)

Human D₂ Receptor

2690 nM (Ki)

All Dopamine Receptor Isoforms :

In Vitro

AB13-08 (compound 4b) (90 min) binds to human D₃ receptors expressed in HEK293 cells with a K_i value of 53.9 nM, and exhibits 49.9-fold binding selectivity over human D₂ receptors (with a K_i value of 2690 nM)^[1].
AB13-08 acts as a full agonist on human D₃ receptors expressed in HEK293T cells, with a potency of 1.10 nM, and exhibits over 2800-fold potency selectivity over human D₂ receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 449.55
화학식 C₂₄H₃₁N₇O₂
SMILES

NC1=NC=C(C=C1)[C@H]2CN([C@H](CO2)C)CCCCNC(C3=CC(C)=CC=C3N4N=CC=N4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Arroyo-Urea S, et al. A Ligand-Triggered Receptor Conformation Enables the Design of Selective Agonists for the Dopamine 3 Receptor (D₃R) Using a Bitopic Strategy. JACS Au. 2026.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
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AB13-08

All Dopamine Receptor Isoforms