AK305
AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a Ki of 0.4 μM for STAT6 and a Ki of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia.
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- CAS No.: 2982853-56-3
- 화학식: C35H40F2N5O7PS2
- 분자량:775.82
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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STAT6 0.4 μM (Ki) |
STAT5a 1 μM (Ki) |
STAT5b 1 μM (Ki) |
AK305 binds with equal affinity to purified STAT5A and STAT5B proteins (Ki = 1.0 μM) and with higher affinity to purified STAT6 protein (Ki = 0.4 μM)[1].
AK305 (5 μM; 18 h) does not alter the levels of any STAT family proteins in SKNO1 AML cells[1].
AK305 (5 μM; 6 h) does not alter the levels of any STAT family proteins in MV4;11 AML cells[1].
AK305 (15 μM; 4 days) does not inhibit cell growth in SKNO1, Kasumi-3, or MV4;11 AML cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SKNO1 acute myeloid leukemia (AML) cells
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Concentration:5 μM
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Incubation Time:18 h
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Result:Exerted no effect on the levels of STAT5A, STAT5B, phosphorylated STAT5 (pSTAT5ᵞ694), STAT1, STAT2, STAT3, STAT4, or STAT6 proteins.
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Cell Line:MV4;11 acute myeloid leukemia (AML) cells
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Concentration:5 μM
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Incubation Time:6 h
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Result:Exerted no effect on the levels of STAT5, phosphorylated STAT5 (pSTAT5ᵞ694), STAT1, STAT2, STAT3, or STAT6 proteins.
Chemical Information
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CAS No. 2982853-56-3
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분자량 775.82
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화학식 C35H40F2N5O7PS2
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SMILES
FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N(CCC(N(C)C)=O)C4=CC=C(C5=NC=CS5)C=C4)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AK305 Related Classifications
HY-184991 Related Classifications
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