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Cat. No.: HY-119731

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Antidesmone

Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum. Antidesmone can prevent acute lung injury in vivo via inhibiting MAPK and NF-κb activities.

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CAS No.: 222629-77-8
화학식: C₁₉H₂₉NO₃
분자량:319.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antidesmone Chemical Structure

CAS No.: 222629-77-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum^[1]. Antidesmone can prevent acute lung injury in vivo via inhibiting MAPK and NF-κb activities^[2].

All p38 MAPK Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.4 μM Compound: 8	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
HeLa	IC₅₀	23.4 μg/mL Compound: 13	Cytotoxicity against human HeLa cells after 48 hrs by SRB assay Cytotoxicity against human HeLa cells after 48 hrs by SRB assay	[PMID: 26848627]
KB	IC₅₀	17.7 μM Compound: 8	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
L6	IC₅₀	184.3 μM Compound: 10	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25314007]
MCF7	IC₅₀	6.4 μM Compound: 8	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MDA-MB-231	IC₅₀	6.7 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
RAW264.7	IC₅₀	16.1 μM Compound: 18	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS stimulation and measured after 20 hrs by Griess reagent based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS stimulation and measured after 20 hrs by Griess reagent based assay	[PMID: 36746775]

Chemical Information

CAS No. 222629-77-8
분자량 319.44
화학식 C₁₉H₂₉NO₃
SMILES

O=C1C(OC)=C(C)NC2=C1[C@@H](CCCCCCCC)CCC2=O
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu X, et al. Antidesmone, a unique tetrahydroquinoline alkaloid, prevents acute lung injury via regulating MAPK and NF-κB activities. Int Immunopharmacol. 2017 Apr;45:34-42. [Content Brief]

[2]. Buske, et al. Antidesmone, a novel type isoquinoline alkaloid from Antidesma membranaceum (Euphorbiaceae). Tetrahedron, 55(4), 1079–1086.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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Antidesmone

All p38 MAPK Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antidesmone Related Classifications

HY-119731 Related Classifications