APGW-amide
APGW-amide is a neuropeptide. APGW-amide controls the growth of imposex structures and promotes growth in Haliotis asinina. APGW-amide inhibits Achatina neurons and modulates neuronal currents induced by neuroactive compounds. APGW-amide induces a rapid increase in [Ca2+]i in Fura-2/AM-loaded PC12 cells. APGW-amide is useful for research on the nervous system.
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- CAS No.: 126675-52-3
- 화학식: C21H28N6O4
- 분자량:428.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
APGW-amide (3 μM) increases the membrane conductance (g) value measured before the Iout caused by erythro-l-BHGA, with ED50, slope, Hill coefficient and Emax were 76.9 msec, 0.89274, 1.59453, and 5.54 nA, respectively[1].
APGW-amide (3 μM) inhibits the Iout, with ED50, slope, Hill coefficient and Emax were 29.5 msec, 1.02386, 1.9761, and 0.38 nA, respectively, increases the g value measured before the Iout induced by Dopamine (HY-B0451)[1].
APGW-amide (3 μM) inhibits the fast component of the Iin caused by Serotonin (HY-B1473A), with ED50, slope, Hill coefficient and Emax were 18.5 msec, 0.8268, 1.6557, and 0.72 nA, respectively[1].
APGW-amide (30 μM) causes a rapid rise of [Ca2+]i in Fura-2/AM-loaded PC12 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
APGW-amide (0.0000001-0.01 nM, every other day, 14 days) induces imposex in the mud snail, Ilyanassa obsoleta[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 126675-52-3
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분자량 428.48
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화학식 C21H28N6O4
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Sequence
Ala-Pro-Gly-Trp-NH2
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Sequence Shortening
APGW-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Han XY, et al. Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: amines and amino acids. Gen Pharmacol. 1997 Oct;29(4):523-30. [Content Brief]
[2]. Han XY, et al. Effect of APGW-amide on [Ca2+]i in rat pheochromocytoma PC12 cells. Jpn J Pharmacol. 2000 Nov;84(3):355-9. [Content Brief]
[4]. Oberdörster E, et al.The neuropeptide APGWamide induces imposex in the mud snail, Ilyanassa obsoleta. Peptides. 2000 Sep;21(9):1323-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APGW-amide Related Classifications
HY-P11082 Related Classifications
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