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Cat. No.: HY-183553

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AUBE00

AUBE00 is an orally active, selective cyclic peptide pan-KRAS inhibitor. AUBE00 selectively binds to the OFF state of KRAS. AUBE00 exhibits anticancer activity against RAS wild-type colorectal cancer. The combination of AUBE00 with Cetuximab (HY-P9905) produces a synergistic antiproliferative effect.

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CAS No.: 2874214-01-2
화학식: C₇₈H₁₁₀F₆N₁₂O₁₄
분자량:1553.77

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AUBE00 Chemical Structure

CAS No.: 2874214-01-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

K-RAS

All Ras Isoforms :

In Vitro

AUBE00 exhibits potent antiproliferative activity against cancer cell lines harboring various KRAS mutations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2874214-01-2
분자량 1553.77
화학식 C₇₈H₁₁₀F₆N₁₂O₁₄
SMILES

CN1C2(CCC2)C(N([C@@H](C3CCCC3)C(N([C@@H](CC(N([C@H](C(N[C@@](C(N4[C@](CCC4)([H])C(N([C@]5([H])C(N(CC/C=C\C5)[C@H](C(N(CC(N[C@H](C(N6[C@](C[C@H](C6)OCC)([H])C1=O)=O)CCC7=CC(OC)=C(C=C7)C(F)(F)F)=O)C)=O)CC8=CC=C(C=C8)C(F)(F)F)=O)C)=O)=O)([H])[C@@H](C)CC)=O)CCC)C)=O)C(N(C)C)=O)C)=O)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Takei K, et al. AUBE00: A novel cyclic peptide pan-KRAS inhibitor targeting KRAS-activated cancers including KRAS-mutant cancers and wild-type colorectal cancer[J]. Cancer Research, 2026, 86(7_Supplement): 5980-5980.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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AUBE00

All Ras Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AUBE00 Related Classifications

HY-183553 Related Classifications