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Cat. No.: HY-182790

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BAA-065

BAA-065 is a selective and orally active PKMYT1 inhibitor with an IC₅₀ of <50 nM. BAA-065 inhibits cancer cells proliferation, induces γH2AX expression and DNA damage. BAA-065 inhibits tumor growth in OVCAR3 xenograft mice. BAA-065 can be used for the research of cancer, such as ovarian cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₅H₃₁N₅O₄S
분자량:497.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BAA-065 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PKMYT1

<50 nM (IC₅₀)

All Wee1 Isoforms :

PKMYT1

In Vitro

BAA-065 (6-500 nM) selectively induces γH2AX expression in multiple sensitive cancer cell lines, modulates cellular biomarkers of cell cycle progression and DNA damage in combination with topoisomerase 1 inhibitor SN38 (HY-13704) in OVCAR3 cells, and affects biomarkers of cell cycle progression in HCC1596 breast cancer cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BAA-065 (160 mg/kg; p.o.; qd for 18 days) inhibits tumor growth in in human ovarian cancer OVCAR3 xenograft mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Human ovarian cancer OVCAR3 xenograft mice models^[1]
Dosage:

160 mg/kg
Administration:

p.o.; qd for 18 days
Result:

Inhibited tumor growth.
Showed stronger antitumor activity combined with antibody-drug conjugate bearing topoisomerase 1 inhibitor payload.

Chemical Information

분자량 497.61
화학식 C₂₅H₃₁N₅O₄S
SMILES

O=C(C1=CN=C(NC2=NC(C(NC(C)(C)C)=O)=CC=C2OC(C)C)S1)NC3=C(C)C=CC(O)=C3C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Deborah SMITHEN, et al. Pkmyt1 inhibitors and their use. WO2026057597. 2026-03-19

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

BAA-065

All Wee1 Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BAA-065 Related Classifications

HY-182790 Related Classifications