Bezafibrate-d6
Based on 1 Customer Validation
Bezafibrate-d6 is the deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
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- Purity: 98.0%
- CAS No.: 1219802-74-0
- 화학식: C19H14D6ClNO4
- 분자량:367.86
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219802-74-0
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Unlabeled Cas 41859-67-0
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Appearance Solid
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분자량 367.86
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화학식 C19H14D6ClNO4
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Color White to light yellow
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SMILES
OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])OC(C=C1)=CC=C1CCNC(C2=CC=C(C=C2)Cl)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 30 mg/mL (81.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 30 mg/mL (81.55 mM)
Ethanol : ≥ 3 mg/mL (8.16 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [Content Brief]
[3]. Usui-Ouchi A, et al. The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cell [Content Brief]
[4]. Franko A, et al. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol Metab. 2017 Jan 6;6(3):256-266. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / DMF | 1 mM | 2.7184 mL | 13.5921 mL | 27.1843 mL | 67.9606 mL |
| 5 mM | 0.5437 mL | 2.7184 mL | 5.4369 mL | 13.5921 mL | |
| DMSO / DMF | 10 mM | 0.2718 mL | 1.3592 mL | 2.7184 mL | 6.7961 mL |
| 15 mM | 0.1812 mL | 0.9061 mL | 1.8123 mL | 4.5307 mL | |
| 20 mM | 0.1359 mL | 0.6796 mL | 1.3592 mL | 3.3980 mL | |
| 25 mM | 0.1087 mL | 0.5437 mL | 1.0874 mL | 2.7184 mL | |
| 30 mM | 0.0906 mL | 0.4531 mL | 0.9061 mL | 2.2654 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6990 mL | |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL | 1.3592 mL | |
| 60 mM | 0.0453 mL | 0.2265 mL | 0.4531 mL | 1.1327 mL | |
| 80 mM | 0.0340 mL | 0.1699 mL | 0.3398 mL | 0.8495 mL |
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