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Cat. No.: HY-114641

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BIIL-260

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with the K_i value of 1.7 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 204974-93-6
화학식: C₃₀H₃₀N₂O₃
분자량:466.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

BIIL-260 Chemical Structure

CAS No.: 204974-93-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Ki: 1.7 nM (LTB₄ receptor)^[1]

All Leukotriene Receptor Isoforms :

In Vitro

BIIL-260 potently inhibits LTB₄-induced intracellular Ca²⁺ release in human neutrophils with the IC₅₀ value of 0.82 nM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 204974-93-6
분자량 466.57
화학식 C₃₀H₃₀N₂O₃
SMILES

N=C(N)C1=CC=C(C=C1)OCC2=CC=CC(COC3=CC=C(C=C3)C(C4=CC=C(C=C4)O)(C)C)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Leukoc Biol

Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [Abstract]

2025 Jun 6:qiaf082. PMID: 40476443

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
순도&문서
References

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BIIL-260

Publications Citing Use of MedChemExpress (MCE) BIIL-260

All Leukotriene Receptor Isoforms