country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P10775A

Copy Link Print Information

BT1769 acetate

고객리뷰

Based on 1 Customer Validation

BT1769 acetate is a conjugate and antitumor agent targeting MT1-MMP, with a K_d value of 3.35 nM against human targets. BT1769 acetate exhibits favorable pharmacokinetic properties. BT1769 acetate specifically binds to MT1-MMP via its bicyclic peptide component, delivering the cytotoxic agent MMAE (HY-15162) to antigen-expressing cells. It effectively inhibits tumor growth, induces complete responses, and significantly prolongs event-free survival in osteosarcoma patient-derived xenograft models. BT1769 acetate shows extremely low activity in Ewing sarcoma models and can be used in osteosarcoma-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₈₆H₂₆₉N₄₃O₅₀S·xC₂H₄O₂
분자량:3939.45 (free base)

보관:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

맞춤형 펩타이드 합성

BT1769 acetate Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All MMP Isoforms :

In Vitro

BT1769 acetate (1.5625-100 nnM) binds to recombinant human MT1-MMP with a K_D of 3.35 nM and to recombinant mouse MT1-MMP with a K_D of 2.99 nM, showing high target affinity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BT1769 (acetate) (3.2 mg/kg; i.v.; once weekly) induces significant antitumor activity in HT1080 osteosarcoma xenografts in female BALB/c nude mice^[2].
BT1769 (acetate) (3 mg/kg; i.v.; once weekly; 4 weeks) significantly prolongs event-free survival and induces maintained complete responses in most tested osteosarcoma patient-derived xenograft models in female CB17SC scid^-/- mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CB17SC scid^-/- Mice (female, 5 to 8 weeks, subcutaneous flank xenografts with 6 distinct osteosarcoma patient-derived models: OS1, OS9, OS17, OS2, OS31, OS33)^[2]
Dosage:

3 mg/kg
Administration:

i.v.; once weekly; 4 consecutive weeks
Result:

Induced significantly prolonged event-free survival (EFS) in all 6 osteosarcoma models.
Achieved maintained complete responses (MCR) in 3 of the 6 models.
Had initial MCR followed by tumor recurrence at 9 weeks post-treatment in the OS17 model, correlating with a reduction in MT1-MMP expression.
Caused an average maximum weight loss of 6.8% across all models, indicating general tolerability.

Chemical Information

Appearance Solid
분자량 3939.45 (free base)
화학식 C₁₈₆H₂₆₉N₄₃O₅₀S·xC₂H₄O₂
선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 50 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Abstract LB008: Integrative surfaceome profiling identifies immunotherapeutic targets in osteosarcomas (OS); Preclinical testing of BT1769, an MT1-MMP-targeted Bicycle Toxin Conjugate, in OS by the Pediatric Preclinical Testing Consortium (PPTC)[J]. Cancer Research, 2021, 81(13_Supplement): LB008-LB008.

[2]. Wang Y, et al. Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma. Mol Cancer Ther. 2022;21(6):903-913. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BT1769 acetate

All MMP Isoforms